All Phenotypes Ralbp1<Gt(OST359995)Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ralbp1^{Gt(OST359995)Lex}
gene trap OST359995, Lexicon Genetics
MGI:3530809

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ralbp1^{Gt(OST359995)Lex}/Ralbp1^{Gt(OST359995)Lex}	B6;129S5-Ralbp1^{Gt(OST359995)Lex}/Ieg	MGI:5428691
hm2	Ralbp1^{Gt(OST359995)Lex}/Ralbp1^{Gt(OST359995)Lex}	involves: 129S5/SvEvBrd * C57BL	MGI:3590312
ht3	Ralbp1^{Gt(OST359995)Lex}/Ralbp1⁺	involves: 129S5/SvEvBrd * C57BL	MGI:3590313

Allelic Composition	Ralbp1^{Gt(OST359995)Lex}/Ralbp1^{Gt(OST359995)Lex}
Genetic Background	B6;129S5-Ralbp1^{Gt(OST359995)Lex}/Ieg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralbp1^{Gt(OST359995)Lex} mutation (2 available); any Ralbp1 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:82809 )

• decreased exploratory activity

decreased locomotor activity ( J:82809 )

• decreased locomotor activity

hypoalgesia ( J:82809 )

• decreased sensitivity to pain

Allelic Composition	Ralbp1^{Gt(OST359995)Lex}/Ralbp1^{Gt(OST359995)Lex}
Genetic Background	involves: 129S5/SvEvBrd * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralbp1^{Gt(OST359995)Lex} mutation (2 available); any Ralbp1 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:100087 )

• survival after X-ray exposure is significantly shorter for homozygotes compared to heterozygotes and wild-type mice

cellular

oxidative stress ( J:100087 )

• markers of oxidative stress are increased, activities of GSH-linked antioxidant enzymes are decreased, and levels of GSH are increased

• changes are greater in homozygotes than in heterozygotes and changes are greater in males than in females

Allelic Composition	Ralbp1^{Gt(OST359995)Lex}/Ralbp1⁺
Genetic Background	involves: 129S5/SvEvBrd * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralbp1^{Gt(OST359995)Lex} mutation (2 available); any Ralbp1 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:100087 )

• survival after X-ray exposure is significantly shorter for homozygotes compared to wild-type mice

cellular

oxidative stress ( J:100087 )

• markers of oxidative stress are increased, activities of GSH-linked antioxidant enzymes are decreased, and levels of GSH are increased

• changes are greater in homozygotes than in heterozygotes and changes are greater in males than in females

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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