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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnmdtm1Ref
targeted mutation 1, Reinhard Fassler
MGI:3530136
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnmdtm1Ref/Tnmdtm1Ref involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3530624
cx2
Cnmdtm1Ref/Cnmdtm1Ref
Tnmdtm1Ref/Tnmdtm1Ref
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3530626


Genotype
MGI:3530624
hm1
Allelic
Composition
Tnmdtm1Ref/Tnmdtm1Ref
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnmdtm1Ref mutation (0 available); any Tnmd mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• significant reduction of cells in 2-week-old patellaris and Achilles tendon and a decrease of proliferating cells in Achilles, patellaris and metatarsal tendons of the newborn hindlimb, however size of Achilles tendon was not altered, localization and number of endothelial cells was normal in Achilles and patellaris tendons, and vessel density in tendons was unaltered in homozygous females and hemizygous males
• 6 month old Achilles tendon had a greater variation of collagen fibril calibers with a higher proportion of thick fibrils and fibrillar surfaces of tendons were uneven and rough

skeleton
N
• homozygous females and hemizygous males showed no size differences, malformations, or signs of contractures of the skeleton and the muscle, thymus, heart, liver, spleen, and lung appeared normal
• significant reduction of cells in 2-week-old patellaris and Achilles tendon and a decrease of proliferating cells in Achilles, patellaris and metatarsal tendons of the newborn hindlimb, however size of Achilles tendon was not altered, localization and number of endothelial cells was normal in Achilles and patellaris tendons, and vessel density in tendons was unaltered in homozygous females and hemizygous males
• 6 month old Achilles tendon had a greater variation of collagen fibril calibers with a higher proportion of thick fibrils and fibrillar surfaces of tendons were uneven and rough

vision/eye
N
• retinas and retinal vasculature of homozygous females and hemizygous males showed no differences from wild-type under normal conditions or after oxygen-induced retinopathy




Genotype
MGI:3530626
cx2
Allelic
Composition
Cnmdtm1Ref/Cnmdtm1Ref
Tnmdtm1Ref/Tnmdtm1Ref
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnmdtm1Ref mutation (0 available); any Cnmd mutation (24 available)
Tnmdtm1Ref mutation (0 available); any Tnmd mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• retinas and retinal vasculature of double homozygotes showed no differences from wild-type under normal conditions or after oxygen-induced retinopathy





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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory