Phenotypes associated with this allele

• Allele Symbol: Npm1^{Gt(OST331547)Lex}
• Allele Name: gene trap OST331547, Lexicon Genetics
• Allele ID: MGI:3529824
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npm1^Gt(OST331547)Lex/Npm1^Gt(OST331547)Lex	B6;129S5-Npm1^Gt(OST331547)Lex/Mmucd	MGI:5442746
hm2	Npm1^Gt(OST331547)Lex/Npm1^Gt(OST331547)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609791
ht3	Npm1^Gt(OST331547)Lex/Npm1^+	B6;129S5-Npm1^Gt(OST331547)Lex/Mmucd	MGI:5442748

Genotype
MGI:5442746

hm1

• Allelic Composition: Npm1^{Gt(OST331547)Lex}/Npm1^{Gt(OST331547)Lex}
• Genetic Background: B6;129S5-Npm1^{Gt(OST331547)Lex}/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:188985 )

Genotype
MGI:3609791

hm2

• Allelic Composition: Npm1^{Gt(OST331547)Lex}/Npm1^{Gt(OST331547)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

mortality/aging

neonatal lethality, complete penetrance ( J:103485 )

• a single genotyped homozygous mouse died shortly after birth

Genotype
MGI:5442748

ht3

• Allelic Composition: Npm1^{Gt(OST331547)Lex}/Npm1⁺
• Genetic Background: B6;129S5-Npm1^{Gt(OST331547)Lex}/Mmucd

hematopoietic system

hematopoietic system phenotype ( J:188985 )

N • unlike Npm1^tm1Ppp heterozygotes, mice exhibit normal blood counts

N • the total number and frequency of methylcellulose colony-forming unit (CFU)-granulocyte/monocyte and CFU-granulocyte/erythrocyte/monocyte/megakaryocyte is normal

increased hematopoietic stem cell number ( J:188985 )

• 1.4-fold

abnormal hematopoietic stem cell physiology ( J:188985 )

• hematopoietic stem cells exhibit reduced engraftment potential compared with control cells