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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk12tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529030
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mapk12tm1Lex/Mapk12tm1Lex
Tg(Myog-cre)1Eno/0 		involves: 129S/SvEvBrd MGI:4415789


Genotype
MGI:4415789
cn1
Allelic
Composition		 Mapk12tm1Lex/Mapk12tm1Lex
Tg(Myog-cre)1Eno/0
Genetic
Background		 involves: 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk12tm1Lex mutation (1 available); any Mapk12 mutation (19 available)
Tg(Myog-cre)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased angiogenesis ( J:155408 )
• marker expression indicates that exercise-induced angiogenesis is decreased compared to in similarly treated wild-type mice

cellular
decreased mitochondrial fission ( J:155408 )
• marker expression indicates that exercise-induced mitochondrial biogenesis is decreased compared to in similarly treated wild-type mice

muscle
muscle phenotype ( J:155408 )
N
• mice exhibit normal fiber-type transformation in response to endurance exercise




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory