Phenotypes associated with this allele

• Allele Symbol: Rgs7^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528964
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs7^tm1Lex/Rgs7^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609859
cx2	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1Lex/Rgs7^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3850242

Genotype
MGI:3609859

hm1

• Allelic Composition: Rgs7^tm1Lex/Rgs7^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:103485 )

• seen in an open field test

decreased locomotor activity ( J:103485 )

• seen in an open field test

homeostasis/metabolism

impaired glucose tolerance ( J:103485 )

• seen in homozygous males

vision/eye

abnormal rod electrophysiology ( J:150122 )

• scotopic b-wave electroretinogram responses are delayed compared to in wild-type mice

• negative-scotopic threshold response is reduced compared to in wild-type mice

• however, photoreceptor-derived a-waves are normal

Genotype
MGI:3850242

cx2

• Allelic Composition: Rgs11^tm1Lex/Rgs11^tm1Lex; Rgs7^tm1Lex/Rgs7^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

vision/eye

abnormal eye electrophysiology ( J:150122 )

• mice exhibit additive effects on time course of the dark-adapted electroretinogram responses arising from bipolar cells

abnormal rod electrophysiology ( J:150122 )

• negative-scotopic threshold response is reduced compared to in wild-type mice or single mutants