Phenotypes associated with this allele

• Allele Symbol: Adgrg6^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528728
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgrg6^tm1Lex/Adgrg6^tm1Lex	involves: 129S/SvEvBrd	MGI:5523458
hm2	Adgrg6^tm1Lex/Adgrg6^tm1Lex	involves: 129S/SvEvBrd * C57BL/6	MGI:5140542

Genotype
MGI:5523458

hm1

• Allelic Composition: Adgrg6^tm1Lex/Adgrg6^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

myocardial trabeculae hypoplasia ( J:202002 )

• hypotrabeculation and thinner trabeculae at E11.25

muscle

myocardial trabeculae hypoplasia ( J:202002 )

• hypotrabeculation and thinner trabeculae at E11.25

Genotype
MGI:5140542

hm2

• Allelic Composition: Adgrg6^tm1Lex/Adgrg6^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:173574 )

• only 7.8% of live births from heterozygote matings are homozygous

preweaning lethality, complete penetrance ( J:173574 )

• all homozygotes die before weaning, usually between 8 and 16 days of age

growth/size/body

decreased body size ( J:173574 )

• significantly under sized at 1 week of age

postnatal growth retardation ( J:173574 )

• fail to grow after birth at the normal rate

• normal size at birth

behavior/neurological

impaired limb coordination ( J:173574 )

• attempts by 12 day old mice to move were uncoordinated

akinesia ( J:173574 )

• mice are immobile by 12 days of age

skeleton

joint contracture ( J:173574 )

• abnormal joint contracture of both the fore- and hind-limb

• sometimes observed as early as birth and readily observable by P4

nervous system

abnormal Schwann cell morphology ( J:173574 )

• development delayed at 1 day of age

• arrested at promyelinating stage

abnormal axon fasciculation ( J:173574 )

• flattened perineural fibroblasts appear in axons as early as 4 days of age

abnormal axon radial sorting ( J:173574 )

• very few axons sorted away from axon bundles

• eventually sorted axons and form basal lamina between 4 and 12 days of age

abnormal axon morphology ( J:173574 )

• no Remak bundles observed at 4-12 days of age

• axon numbers are much reduced at 8 days

abnormal somatic nervous system morphology ( J:173574 )

abnormal cochlear nerve morphology ( J:173574 )

• no myelination in peripheral regions whereas myelin is present centrally

• central projections of myelin sheath outward from central areas into more peripheral regions of the nerve

abnormal sciatic nerve morphology ( J:173574 )

• reduced in size

• hypomyelinated

abnormal myelination ( J:173574 )

• sciatic nerve hypomyelinated

• optic nerve myelination normal

cellular

abnormal Schwann cell morphology ( J:173574 )

• development delayed at 1 day of age

• arrested at promyelinating stage

abnormal axon fasciculation ( J:173574 )

• flattened perineural fibroblasts appear in axons as early as 4 days of age