Phenotypes associated with this allele

• Allele Symbol: Tg(SERPINA1-HBVX)1655Jtsb
• Allele Name: transgene insertion 1655, Janet S Butel
• Allele ID: MGI:3528241
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(IRS1)1Mhep/0 Tg(SERPINA1-HBVX)1655Jtsb/0	involves: C3H * C57BL/6 * FVB * ICR	MGI:5706939
tg2	Tg(SERPINA1-HBVX)1655Jtsb/0	involves: C3H * C57BL/6 * ICR	MGI:5706933

Genotype
MGI:5706939

cx1

• Allelic Composition: Tg(IRS1)1Mhep/0; Tg(SERPINA1-HBVX)1655Jtsb/0
• Genetic Background: involves: C3H * C57BL/6 * FVB * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

hepatic steatosis ( J:227278 )

• 9 month old males exhibit substantial dysplastic, steatosis and lobular architectural changes in the liver

• 9 month old females exhibit only mild steatosis

increased hepatocellular carcinoma incidence ( J:227278 )

♂ • males, but not females, develop hepatocellular carcinoma starting at 15-18 months of age

♂ • tumors vary in appearance, size and location, from multiple tiny nodules covering the entire liver to a single large mass

neoplasm

increased hepatocellular carcinoma incidence ( J:227278 )

♂ • males, but not females, develop hepatocellular carcinoma starting at 15-18 months of age

♂ • tumors vary in appearance, size and location, from multiple tiny nodules covering the entire liver to a single large mass

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:227278

Genotype
MGI:5706933

tg2

• Allelic Composition: Tg(SERPINA1-HBVX)1655Jtsb/0
• Genetic Background: involves: C3H * C57BL/6 * ICR

liver/biliary system

liver inflammation ( J:90305 )

• mild focal lobular hepatitis is seen in mice of all ages

abnormal liver morphology ( J:90305 )

• most mice over 4 months of age have mild nuclear pleomorphism of hepatocytes that is not progressive, increased mitotic activity of hepatocytes, rare focal liver necrosis and liver infarcts

immune system

liver inflammation ( J:90305 )

• mild focal lobular hepatitis is seen in mice of all ages