Phenotypes associated with this allele

• Allele Symbol: Card11^tm1Vmd
• Allele Name: targeted mutation 1, Vishva M Dixit
• Allele ID: MGI:3528226
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card11^tm1Vmd/Card11^tm1Vmd	involves: 129S6/SvEvTac * C57BL/6N	MGI:3528445
ht2	Card11^tm1Vmd/Card11^+	involves: 129S6/SvEvTac * C57BL/6N	MGI:3528448

Genotype
MGI:3528445

hm1

• Allelic Composition: Card11^tm1Vmd/Card11^tm1Vmd
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell proliferation ( J:95800 )

• antibody-stimulated T cells fail to grow and proliferate and fewer mutant T cells are viable following stimulation (14% compared to 35% of wild-type T cells)

• addition of exogenous IL-2 restores T cell proliferation

absent immature B cells ( J:95800 )

• no B220+ IgM+ CD5+ B cells are found in the peritoneum

abnormal B cell physiology ( J:95800 )

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

decreased IgA level ( J:95800 )

• levels of IgA are below detection in 7 out of 9 nave homozygotes

decreased IgG level ( J:95800 )

• levels of IgG2b and IgG3 isotypes are below detection and levels of IgG1 and IgG2a are reduced to 36-40% of wild-type

decreased IgG1 level ( J:95800 )

decreased IgG2a level ( J:95800 )

decreased IgG2b level ( J:95800 )

decreased IgG3 level ( J:95800 )

decreased IgM level ( J:95800 )

• levels of IgM are below detection

immune system

decreased T cell proliferation ( J:95800 )

• antibody-stimulated T cells fail to grow and proliferate and fewer mutant T cells are viable following stimulation (14% compared to 35% of wild-type T cells)

• addition of exogenous IL-2 restores T cell proliferation

absent immature B cells ( J:95800 )

• no B220+ IgM+ CD5+ B cells are found in the peritoneum

abnormal B cell physiology ( J:95800 )

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

decreased IgA level ( J:95800 )

• levels of IgA are below detection in 7 out of 9 nave homozygotes

decreased IgG level ( J:95800 )

• levels of IgG2b and IgG3 isotypes are below detection and levels of IgG1 and IgG2a are reduced to 36-40% of wild-type

decreased IgG1 level ( J:95800 )

decreased IgG2a level ( J:95800 )

decreased IgG2b level ( J:95800 )

decreased IgG3 level ( J:95800 )

decreased IgM level ( J:95800 )

• levels of IgM are below detection

cellular

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

decreased T cell proliferation ( J:95800 )

• antibody-stimulated T cells fail to grow and proliferate and fewer mutant T cells are viable following stimulation (14% compared to 35% of wild-type T cells)

• addition of exogenous IL-2 restores T cell proliferation

Genotype
MGI:3528448

ht2

• Allelic Composition: Card11^tm1Vmd/Card11⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

immune system

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

hematopoietic system

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

cellular

decreased B cell proliferation ( J:95800 )

• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation