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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rassf1tm1Gpp
targeted mutation 1, Gerd P Pfeifer
MGI:3528065
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rassf1tm1Gpp/Rassf1tm1Gpp involves: 129S1/SvImJ MGI:5784898
hm2
 		Rassf1tm1Gpp/Rassf1tm1Gpp involves: 129S1/SvImJ * C57BL/6 MGI:3528191
ht3
 		Rassf1tm1Gpp/Rassf1+ involves: 129S1/SvImJ * C57BL/6 MGI:3528192
cx4
 		Rassf1tm1Gpp/Rassf1tm1Gpp
Sav1tm1.1Gpp/Sav1+ 		involves: 129S1/Sv * 129S1/SvImJ MGI:5784899


Genotype
MGI:5784898
hm1
Allelic
Composition		 Rassf1tm1Gpp/Rassf1tm1Gpp
Genetic
Background		 involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf1tm1Gpp mutation (0 available); any Rassf1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal oval cell morphology ( J:231761 )
• occasionally, livers show signs of oval cell hyperplasia
increased liver tumor incidence ( J:231761 )
• 42% of mice develop liver tumors
• liver tumors vary from small, solitary nodules to large, multinodular masses taking up entire lobes of the liver
increased hepatocellular carcinoma incidence ( J:231761 )
• 8.9% of mice exhibit hepatocellular carcinoma
• 2.2% of mice exhibit mixed hepatocellular carcinoma
increased liver adenoma incidence ( J:231761 )
• 31.1% of mice exhibit hepatocellular adenoma
• 4.4% of mice exhibit mixed hepatocellular adenoma

neoplasm
increased liver tumor incidence ( J:231761 )
• 42% of mice develop liver tumors
• liver tumors vary from small, solitary nodules to large, multinodular masses taking up entire lobes of the liver
increased hepatocellular carcinoma incidence ( J:231761 )
• 8.9% of mice exhibit hepatocellular carcinoma
• 2.2% of mice exhibit mixed hepatocellular carcinoma
increased liver adenoma incidence ( J:231761 )
• 31.1% of mice exhibit hepatocellular adenoma
• 4.4% of mice exhibit mixed hepatocellular adenoma

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:231761 )
N
• mice do not exhibit bile duct hyperplasia




Genotype
MGI:3528191
hm2
Allelic
Composition		 Rassf1tm1Gpp/Rassf1tm1Gpp
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf1tm1Gpp mutation (0 available); any Rassf1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:95683 )
• benzo(a)pyrene induced significantly larger skin tumors and about 50% of these tumors were squamous cell carcinomas which are not seen in wild-type mice
• urethane exposure resulted in increased tumor load and multiplicity in homozygotes compared to wild-type mice
increased lung adenoma incidence ( J:95683 )
• 5 out of 41 homozygotes had lung adenomas consisting of circumscribed but nonencapsulated closely packed acini of cuboidal and low columnar epithelial cells and some had papillary formations or nuclear pleomorphisms
increased B cell derived lymphoma incidence ( J:95683 )
• 4 out of 41 homozygotes had high-grade B cell lymphomas
• individual cases of leukemia, breast adenocarcinoma, and rectal papilloma were also seen

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:95683 )
• benzo(a)pyrene induced significantly larger skin tumors and about 50% of these tumors were squamous cell carcinomas which are not seen in wild-type mice
• urethane exposure resulted in increased tumor load and multiplicity in homozygotes compared to wild-type mice

respiratory system
increased lung adenoma incidence ( J:95683 )
• 5 out of 41 homozygotes had lung adenomas consisting of circumscribed but nonencapsulated closely packed acini of cuboidal and low columnar epithelial cells and some had papillary formations or nuclear pleomorphisms




Genotype
MGI:3528192
ht3
Allelic
Composition		 Rassf1tm1Gpp/Rassf1+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf1tm1Gpp mutation (0 available); any Rassf1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:95683 )
• benzo(a)pyrene induced significantly larger skin tumors and about 50% of these tumors were squamous cell carcinomas which are not seen in wild-type mice
• urethane exposure resulted in increased tumor load and multiplicity in heterozygotes compared to wild-type mice
increased lung adenoma incidence ( J:95683 )
• 4 out of 35 heterozygotes had lung adenomas
• individual cases of high-grade B cell lymphoma and sarcoma were also seen

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:95683 )
• benzo(a)pyrene induced significantly larger skin tumors and about 50% of these tumors were squamous cell carcinomas which are not seen in wild-type mice
• urethane exposure resulted in increased tumor load and multiplicity in heterozygotes compared to wild-type mice

respiratory system
increased lung adenoma incidence ( J:95683 )
• 4 out of 35 heterozygotes had lung adenomas
• individual cases of high-grade B cell lymphoma and sarcoma were also seen




Genotype
MGI:5784899
cx4
Allelic
Composition		 Rassf1tm1Gpp/Rassf1tm1Gpp
Sav1tm1.1Gpp/Sav1+
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf1tm1Gpp mutation (0 available); any Rassf1 mutation (26 available)
Sav1tm1.1Gpp mutation (0 available); any Sav1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
bile duct hyperplasia ( J:231761 )
• about 15-20% of mice show bile duct hyperplasia compared to about 7% of wild-type mice

liver/biliary system
bile duct hyperplasia ( J:231761 )
• about 15-20% of mice show bile duct hyperplasia compared to about 7% of wild-type mice
abnormal oval cell morphology ( J:231761 )
• more than 50% of mice show signs of oval cell hyperplasia
increased liver tumor incidence ( J:231761 )
• 90% of mice develop liver tumors
increased hepatoblastoma incidence ( J:231761 )
• 2.6% of mice exhibit hepatoblastoma
increased hepatocellular carcinoma incidence ( J:231761 )
• 77% of mice exhibit hepatocellular carcinoma
• 23.1% of mice exhibit mixed hepatocellular carcinoma
increased liver adenoma incidence ( J:231761 )
• 79.5% of mice exhibit hepatocellular adenoma
• 38.5% of mice exhibit mixed hepatocellular adenoma

neoplasm
increased liver tumor incidence ( J:231761 )
• 90% of mice develop liver tumors
increased hepatoblastoma incidence ( J:231761 )
• 2.6% of mice exhibit hepatoblastoma
increased hepatocellular carcinoma incidence ( J:231761 )
• 77% of mice exhibit hepatocellular carcinoma
• 23.1% of mice exhibit mixed hepatocellular carcinoma
increased liver adenoma incidence ( J:231761 )
• 79.5% of mice exhibit hepatocellular adenoma
• 38.5% of mice exhibit mixed hepatocellular adenoma




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory