All Phenotypes Tg(Wap-cre)1Gsc MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Wap-cre)1Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:3527493
cn2	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Itgb1^tm1Mll/Itgb1^tm1Mll Tg(Wap-cre)1Gsc/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3706341
cn3	Itgb1^tm1Mll/Itgb1^tm1Mll Tg(Wap-cre)1Gsc/0	involves: 129X1/SvJ * FVB/N	MGI:3706335
cn4	Gt(ROSA)26Sor^{tm1(CAG-PIK3CA*H1047R,-EGFP)Balj}/Gt(ROSA)26Sor⁺ Tg(Wap-cre)1Gsc/0	involves: BALB/c * C57BL/6 * FVB/N	MGI:5052138

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:95548 )

• between day 14.5 of pregnancy (P14.5) and P18.5, lobuloalveolar development was retarded, however milk protein expression is normal and females are able to nurse pups although pups weight 20% less during the first 10 days after birth

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy

abnormal mammary gland alveolus morphology ( J:95548 )

• although secretory alveoli form, less space is occupied by epithelial structures and more space is occupied by fat compared to controls during pregnancy and throughout lactation indicating that alveolar lobes do not completely penetrate the mammary fat pad

reproductive system

abnormal mammary gland growth during pregnancy ( J:95548 )

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy

integument

abnormal mammary gland growth during pregnancy ( J:95548 )

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy

abnormal mammary gland alveolus morphology ( J:95548 )

Allelic Composition	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Itgb1^tm1Mll/Itgb1^tm1Mll Tg(Wap-cre)1Gsc/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^tm1Tyj mutation (3 available); any Cdkn1a mutation (60 available)
Itgb1^tm1Mll mutation (1 available); any Itgb1 mutation (59 available)
Tg(Wap-cre)1Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:99405 )

• mutants show a decrease in cell proliferation in mammary glands compared to wild-type, however they show a significant increase in cell proliferation compared to the conditional Itgb1 mutant glands, which represents a partial, 55%, reversion of the phenotype

integument

abnormal mammary gland growth during lactation ( J:99405 )

Allelic Composition	Itgb1^tm1Mll/Itgb1^tm1Mll Tg(Wap-cre)1Gsc/0
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm1Mll mutation (1 available); any Itgb1 mutation (59 available)
Tg(Wap-cre)1Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:99405 )

• at lactation day 5, mammary glands have defects in alveolar integrity, with detachment of luminal epithelial cells resulting in an 11-fold increase in luminally shed and bulging cells due to alterations in cell-basement membrane associations

• the defect in alveolar integrity becomes more pronounced during a second lactation

• density of the lobular-alveolar structures is decreased at day 5 of the first, and more strongly, the second lactation

abnormal mammary gland growth during lactation ( J:99405 )

• luminal cell proliferation is reduced in mammary glands at day 5 of lactation

integument

abnormal mammary gland morphology ( J:99405 )

• the defect in alveolar integrity becomes more pronounced during a second lactation

• density of the lobular-alveolar structures is decreased at day 5 of the first, and more strongly, the second lactation

abnormal mammary gland growth during lactation ( J:99405 )

• luminal cell proliferation is reduced in mammary glands at day 5 of lactation

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-PIK3CA*H1047R,-EGFP)Balj}/Gt(ROSA)26Sor⁺ Tg(Wap-cre)1Gsc/0
Genetic Background	involves: BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-PIK3CA*H1047R,-EGFP)Balj} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Wap-cre)1Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:173655 )

• delayed due to reduced cell death

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )

integument

abnormal involution of the mammary gland ( J:173655 )

• delayed due to reduced cell death

increased mammary gland tumor incidence ( J:173655 )

• parous mice develop mammary tumors 37 days after delivery of pups (at 140 days) unlike Tg(Wap-cre)1Gsc mice

• mammary tumors are heterogeneous (adenosquamous carcinoma, adenomyoepitheliomas, adenocarcinomas with squamouse metaplasia, adenocarcinomas, and adenocarcinomatosis)

increased mammary adenocarcinoma incidence ( J:173655 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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