All Phenotypes Drd1<tm1(cre)Rpa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Drd1^tm1(cre)Rpa
targeted mutation 1, Richard D Palmiter
MGI:3527153

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drd1^tm1(cre)Rpa/Drd1^tm1(cre)Rpa	involves: 129S4/SvJaeSor * C57BL/6	MGI:3806594
cn2	Drd1^tm1(cre)Rpa/Drd1⁺ Gad1^tm1Rpa/Gad1^tm1.1Rpa	involves: 129S4/SvJaeSor * C57BL/6	MGI:3806595
cn3	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Drd1^tm1(cre)Rpa/Drd1⁺	involves: C57BL/6	MGI:5515336

Allelic Composition	Drd1^tm1(cre)Rpa/Drd1^tm1(cre)Rpa
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1^tm1(cre)Rpa mutation (0 available); any Drd1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:138586 )

• authors state that mice behave like Drd1a^tm1Jcd homozygotes

growth/size/body

decreased body size ( J:138586 )

Allelic Composition	Drd1^tm1(cre)Rpa/Drd1⁺ Gad1^tm1Rpa/Gad1^tm1.1Rpa
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1^tm1(cre)Rpa mutation (0 available); any Drd1 mutation (68 available)
Gad1^tm1.1Rpa mutation (0 available); any Gad1 mutation (64 available)
Gad1^tm1Rpa mutation (1 available); any Gad1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:138586 )

N	• mice exhibit normal gait and response to the Drd1a agonist SKF81297

limb grasping ( J:138586 )

abnormal motor coordination/balance ( J:138586 )

• mice spend more time on a rotarod than heterozygous controls

decreased grip strength ( J:138586 )

• on the second of three trials mice exhibit decreased strength in a modified wire hang test compared to heterozygous controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Drd1^tm1(cre)Rpa/Drd1⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1^tm1(cre)Rpa mutation (0 available); any Drd1 mutation (68 available)
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2b^tm3Gsm mutation (0 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:196157 )

• remain hyperactive

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight similar to controls

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• adiposity similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196157 )

N	• serum leptin levels similar to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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