Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gata4tm1.1Wtp targeted mutation 1.1, William T Pu MGI:3526854 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Growth retardation and myocardial thinning in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice
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• severe
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• severe
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Hearts of Gata4tm1.1Wtp/Gata4tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normal
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• viable with no signs of embryonic growth retardation or myocardial thinning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Hypocellular endocardial cushions in Gata4tm1.1Wtp/Gata4tm1Grg Tg(Tek-cre)1Ywa/0 mice
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• hypocellular endocardial cushions are noted at E10.5
• however, no myocardial thinning is seen
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| N |
• viable with no signs of embryonic growth retardation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Edema, peripheral hemorrhage, and reduced coronary plexus in Gata4tm1.1Wtp/Gata4tm1Sho Nkx2-5tm1(cre)Rjs/Nkx2-5+ embryos and enlarged dilated ventricles and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 hearts
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• compact myocardium is thin
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• atrio-ventricular cushion defect is observed
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• coronary vascular development is impaired
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• ventricular septal defect is observed
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• peripheral hemorrhage is observed at E13.5
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• observed at E13.5
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• observed at E13.5
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• compact myocardium is thin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Reduced coronary microvasculature, decreased capillary density and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 hearts
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• ventricular dilation is observed
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• severely diminished systolic function at 8-14 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lethality by E11.5
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• defect in the EMT of endocardial cells that normally generates cushion mesenchyme
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• the outflow tract endocardial cushions are small and contain few mesenchymal cells
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• the atrioventricular endocardial cushions are small and contain few mesenchymal cells
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• 15 of 21 embryos at E9.5 display a single predominant ventricular chamber that connects to an outflow tract located toward the rostral side of the chamber; the predominant ventricular chamber is the left ventricle
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• all embryos display marked myocardial hypoplasia, affecting both the compact and trabecular myocardium
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• 6 of 21 embryos at E9.5 have a normal to mildy hypoplastic right ventricle, rest have severe right ventricle hypoplasia
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• by E10.5, have large pericardial effusions
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• cardiomyocyte proliferation is more severely reduced in the right ventricle than in the left ventricle
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• by E10.5, embryos are mildly delayed in overall development
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• cardiomyocyte proliferation is more severely reduced in the right ventricle than in the left ventricle
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• by E10.5, embryos are mildly delayed in overall development
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• by E10.5, have large pericardial effusions
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• cardiomyocyte proliferation is more severely reduced in the right ventricle than in the left ventricle
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lethality by E14.5
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• marked myocardial hyperplasia
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• reduction in cardiomyocyte proliferation
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• reduction in cardiomyocyte proliferation
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• reduction in cardiomyocyte proliferation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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