Phenotypes associated with this allele

• Allele Symbol: Slc6a1^tm1Lst
• Allele Name: targeted mutation 1, Henry A Lester
• Allele ID: MGI:3526678
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a1^tm1Lst/Slc6a1^tm1Lst	involves: 129S1/Sv * C57BL/6	MGI:3526888

Genotype
MGI:3526888

hm1

• Allelic Composition: Slc6a1^tm1Lst/Slc6a1^tm1Lst
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:95639 )

• a 64% reduction in miniature inhibitory postsynaptic currents and an increase in tonic postsynaptic currents are seen

abnormal neurotransmitter secretion ( J:95639 )

• the frequency of quantal GABA release is reduced to 1/3 of wild-type

abnormal neurotransmitter uptake ( J:95639 )

• NO-711 sensitive GABA uptake activity is less than 2% of wild-type and extracellular levels of GABA are elevated