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Slc6a1tm1Lst
Targeted Allele Detail
Summary
Symbol: Slc6a1tm1Lst
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1; targeted mutation 1, Henry A Lester
MGI ID: MGI:3526678
Synonyms: GAT-1 KO
Gene: Slc6a1  Location: Chr6:114259735-114294491 bp, + strand  Genetic Position: Chr6, 53.05 cM, cytoband E3
Alliance: Slc6a1tm1Lst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80438
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph, Reporter)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin cassette was inserted in intron 14. A GFP gene was inserted in exon 15 at the 3' end of the coding sequence. The resulting mice are hypomorphic with respect to expression. (J:80438, J:95639)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a1 Mutation:  51 strains or lines available
References
Original:  J:80438 Chiu CS, et al., Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. J Neurosci. 2002 Dec 1;22(23):10251-66
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory