All Phenotypes Fgf10<tm1.1Sms> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgf10^tm1.1Sms
targeted mutation 1.1, Suzanne L Mansour
MGI:3526181

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf10^tm1.1Sms/Fgf10^tm1.1Sms	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ	MGI:4456408
hm2	Fgf10^tm1.1Sms/Fgf10^tm1.1Sms	involves: 129S1/Sv * 129X1/SvJ	MGI:3851798
ht3	Fgf10^tm1Wss/Fgf10^tm1.1Sms	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ	MGI:4456411
cx4	Fgf10^tm1.1Sms/Fgf10^tm1.1Sms Fgf3^tm1.1Sms/Fgf3^tm1.1Sms	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ	MGI:4456406

Allelic Composition	Fgf10^tm1.1Sms/Fgf10^tm1.1Sms
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1.1Sms mutation (0 available); any Fgf10 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

hearing/vestibular/ear

abnormal ear morphology ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

respiratory system

abnormal respiratory system morphology ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

Allelic Composition	Fgf10^tm1.1Sms/Fgf10^tm1.1Sms
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1.1Sms mutation (0 available); any Fgf10 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:150706 )

• mice die at birth due to a lack of lungs

respiratory system

abnormal lung development ( J:150706 )

• lungs fail to develop in these mice

absent lungs ( J:150706 )

Allelic Composition	Fgf10^tm1Wss/Fgf10^tm1.1Sms
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1.1Sms mutation (0 available); any Fgf10 mutation (32 available)
Fgf10^tm1Wss mutation (0 available); any Fgf10 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

hearing/vestibular/ear

abnormal ear morphology ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

respiratory system

abnormal respiratory system morphology ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

Allelic Composition	Fgf10^tm1.1Sms/Fgf10^tm1.1Sms Fgf3^tm1.1Sms/Fgf3^tm1.1Sms
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1.1Sms mutation (0 available); any Fgf10 mutation (32 available)
Fgf3^tm1.1Sms mutation (0 available); any Fgf3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

absent otic vesicle ( J:160254 )

• mice exhibit small to absent otic vesicles compared with wild-type mice

small otic vesicle ( J:160254 )

• mice exhibit small to absent otic vesicles compared with wild-type mice

limbs/digits/tail

decreased limb number ( J:160254 )

short tail ( J:160254 )

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