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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tex11tm1Jw
targeted mutation 1, Jeremy Wang
MGI:3526163
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tex11tm1Jw/Tex11tm1Jw
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3811495
cn2
Tex11tm1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3811496


Genotype
MGI:3811495
cn1
Allelic
Composition
Tex11tm1Jw/Tex11tm1Jw
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex11tm1Jw mutation (0 available); any Tex11 mutation (20 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• pachytene oocytes contain asynapsed chromosomes unlike in wild-type mice

cellular
• pachytene oocytes contain asynapsed chromosomes unlike in wild-type mice




Genotype
MGI:3811496
cn2
Allelic
Composition
Tex11tm1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex11tm1Jw mutation (0 available); any Tex11 mutation (20 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• some spermatocytes exhibit desynapsis at diplotene due to defective crossover formation during pachytene
• during anaphase, a few chromatin masses migrate ahead or lag behind the two major chromatin masses unlike in wild-type spermatocytes
• sperm cells undergo increased apoptosis compared to in wild-type mice during pachytene and anaphase I
• testes weight is 50% of wild-type

endocrine/exocrine glands
• testes weight is 50% of wild-type

cellular
• some spermatocytes exhibit desynapsis at diplotene due to defective crossover formation during pachytene
• during anaphase, a few chromatin masses migrate ahead or lag behind the two major chromatin masses unlike in wild-type spermatocytes
• sperm cells undergo increased apoptosis compared to in wild-type mice during pachytene and anaphase I





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory