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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tex11tm1Jw
targeted mutation 1, Jeremy Wang
MGI:3526163
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tex11tm1Jw/Tex11tm1Jw
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3811495
cn2
 		Tex11tm1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3811496


Genotype
MGI:3811495
cn1
Allelic
Composition		 Tex11tm1Jw/Tex11tm1Jw
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex11tm1Jw mutation (0 available); any Tex11 mutation (20 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chiasmata formation ( J:131722 )
• pachytene oocytes contain asynapsed chromosomes unlike in wild-type mice

cellular
abnormal chiasmata formation ( J:131722 )
• pachytene oocytes contain asynapsed chromosomes unlike in wild-type mice




Genotype
MGI:3811496
cn2
Allelic
Composition		 Tex11tm1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex11tm1Jw mutation (0 available); any Tex11 mutation (20 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chiasmata formation ( J:131722 )
• some spermatocytes exhibit desynapsis at diplotene due to defective crossover formation during pachytene
meiotic nondisjunction during M1 phase ( J:131722 )
• during anaphase, a few chromatin masses migrate ahead or lag behind the two major chromatin masses unlike in wild-type spermatocytes
increased male germ cell apoptosis ( J:131722 )
• sperm cells undergo increased apoptosis compared to in wild-type mice during pachytene and anaphase I
decreased testis weight ( J:131722 )
• testes weight is 50% of wild-type

endocrine/exocrine glands
decreased testis weight ( J:131722 )
• testes weight is 50% of wild-type

cellular
abnormal chiasmata formation ( J:131722 )
• some spermatocytes exhibit desynapsis at diplotene due to defective crossover formation during pachytene
meiotic nondisjunction during M1 phase ( J:131722 )
• during anaphase, a few chromatin masses migrate ahead or lag behind the two major chromatin masses unlike in wild-type spermatocytes
increased male germ cell apoptosis ( J:131722 )
• sperm cells undergo increased apoptosis compared to in wild-type mice during pachytene and anaphase I




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory