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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk14tm1.1Otsu
targeted mutation 1.1, Kinya Otsu
MGI:3525575
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk14tm1.1Otsu/Mapk14tm1.1Otsu involves: C57BL/6J MGI:3525856
cn2
 		Mapk14tm1.1Otsu/Mapk14tm1.2Otsu
Slc6a3tm1(cre)Xz/0 		involves: 129S1/Sv * C57BL/6 MGI:5824896


Genotype
MGI:3525856
hm1
Allelic
Composition		 Mapk14tm1.1Otsu/Mapk14tm1.1Otsu
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1.1Otsu mutation (0 available); any Mapk14 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5824896
cn2
Allelic
Composition		 Mapk14tm1.1Otsu/Mapk14tm1.2Otsu
Slc6a3tm1(cre)Xz/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1.1Otsu mutation (0 available); any Mapk14 mutation (43 available)
Mapk14tm1.2Otsu mutation (1 available); any Mapk14 mutation (43 available)
Slc6a3tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:226396 )
N
• performance on the rotarod is similar to controls, although there is a slight trend toward improved performance
abnormal associative learning ( J:226396 )
• resistant to agonist U50,488-induced conditioned place aversion (CPA)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory