Mapk14^tm1.1Otsu
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1.1Otsu
• Name: mitogen-activated protein kinase 14; targeted mutation 1.1, Kinya Otsu
• MGI ID: MGI:3525575
• Synonyms: p38alpha^-
• Gene: Mapk14 Location: Chr17:28910303-28967380 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1.1Otsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95116
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated excision deleted the exon encoding part of the catalytic domain and the ATP binding loop (amino acids 40-83). (J:95116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 41 strains or lines available

References

• Original: J:95116 Nishida K, et al., p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol. 2004 Dec;24(24):10611-20
• All: 4 reference(s)