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Allele Symbol Allele Name Allele ID |
Erbb2tm8(Erbb2)Mul targeted mutation 8, William J Muller MGI:3525444 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer
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• 35% incidence of lung metastases compared with 5% in single Erbb2 mutants
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• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer
|
|
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:133305 | |
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer
|
|
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer
|
|
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:133305 | |
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• numerous lobular side buds with acinar structures are observed
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• mice develop precocious lobualveolar hyperplasias of the mammary glands
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• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age
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• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age
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• numerous lobular side buds with acinar structures are observed
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• mice develop precocious lobualveolar hyperplasias of the mammary glands
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• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:167180 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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