All Phenotypes Tmem41b<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tmem41b⁺
wild type
MGI:3525249

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tmem41b^{tm1b(KOMP)Wtsi}/Tmem41b⁺	C57BL/6N-Tmem41b^{tm1b(KOMP)Wtsi}/Kmpc	MGI:6408729
ht2	Tmem41b^em1Cya/Tmem41b⁺	involves: C57BL/6	MGI:6838395

Allelic Composition	Tmem41b^{tm1b(KOMP)Wtsi}/Tmem41b⁺
Genetic Background	C57BL/6N-Tmem41b^{tm1b(KOMP)Wtsi}/Kmpc
Cell Lines	EPD0122_4_A06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem41b^{tm1b(KOMP)Wtsi} mutation (0 available); any Tmem41b mutation (20 available)

Data Sources

IMPC Data for Tmem41b

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating creatine kinase level ( J:211773 )

IMPC - KMPC

Allelic Composition	Tmem41b^em1Cya/Tmem41b⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem41b^em1Cya mutation (1 available); any Tmem41b mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to Coronaviridae infection ( J:316472 )

• display reduced weight loss and delayed disease progression following infection with 5x10^5 plaque forming units of MHV-A59

• liver necrosis and damage are reduced following MHV-A59 infection, with only focal areas of necrosis found compared to extensive necrotic areas in livers of similarly infected wild-type mice

• post infection with MHV-A59 viral titers are lower than in similarly infected wild-type controls

cellular

impaired autophagy ( J:316472 )

• accumulation of p62 in the liver and kidneys indicating impaired autophagic flux

homeostasis/metabolism

impaired autophagy ( J:316472 )

• accumulation of p62 in the liver and kidneys indicating impaired autophagic flux

decreased circulating cholesterol level ( J:316472 )

• lower total cholesterol level in the serum

decreased circulating LDL cholesterol level ( J:316472 )

decreased circulating triglyceride level ( J:316472 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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