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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Top2btm2.1Jcw
targeted mutation 2.1, James C Wang
MGI:3521923
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Top2btm2.1Jcw/Top2btm2.1Jcw involves: 129S4/SvJae * 129S6/SvEvTac MGI:3521930
cn2
 		Top2btm2Jcw/Top2btm2.1Jcw
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ MGI:3521928


Genotype
MGI:3521930
hm1
Allelic
Composition		 Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Top2btm2.1Jcw mutation (0 available); any Top2b mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:94879 )
• died of respiratory failure shortly after birth

growth/size/body
decreased body size ( J:94879 )

respiratory system
respiratory failure ( J:94879 )
• died of respiratory failure

skeleton
abnormal spine curvature ( J:94879 )
• abnormal curvature of the vertebral column

nervous system
abnormal neuronal migration ( J:94879 )
• late born neurons failed to migrate to the superficial layers of the neocortex
abnormal telencephalon development ( J:94879 )
• absent boundary between the intermediate zone and cortical plate
decreased brain size ( J:94879 )
• smaller brain at E16.5 and E18.5 but not at E14.5
abnormal stratification in cerebral cortex ( J:94879 )
• abnormal lamination of the neocortex
small olfactory bulb ( J:94879 )
• barely identifiable at E16.5 and remains poorly developed at E18.5

cellular
abnormal neuronal migration ( J:94879 )
• late born neurons failed to migrate to the superficial layers of the neocortex




Genotype
MGI:3521928
cn2
Allelic
Composition		 Top2btm2Jcw/Top2btm2.1Jcw
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Top2btm2.1Jcw mutation (0 available); any Top2b mutation (91 available)
Top2btm2Jcw mutation (1 available); any Top2b mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:94879 )
• died of respiratory failure within 30 min after birth, however decreased body size was not observed as in homozygous Top2b mutant mice

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:94879 )
• lack the vigor of wild-type newborns, however show some body movements upon tactile stimulation

respiratory system
respiratory failure ( J:94879 )
• collapsed lung alveoli in dead pups suggests respiratory failure

nervous system
abnormal hippocampus granule cell layer ( J:94879 )
• ill-defined granule cell layer in the hippocampus
abnormal hippocampus pyramidal cell layer ( J:94879 )
• ill-defined pyramidal cell layer in the hippocampus
small olfactory bulb ( J:94879 )
• less developed olfactory bulb




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory