All Phenotypes Mrgprd<tm1Mjz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mrgprd^tm1Mjz
targeted mutation 1, Mark J Zylka
MGI:3521853

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrgprd^tm1Mjz/Mrgprd^tm1Mjz	B6.129S1-Mrgprd^tm1Mjz	MGI:3852410
hm2	Mrgprd^tm1Mjz/Mrgprd^tm1Mjz	involves: 129S1/Sv	MGI:3717723
ht3	Mrgprd^tm1Mjz/Mrgprd^{tm2.1(Hbegf)Mjz}	involves: 129S1/Sv	MGI:3849872
ht4	Mrgprd^tm1Mjz/Mrgprd^tm3(DTA)Mjz	involves: 129S1/Sv	MGI:3849873
cn5	Mrgprd^tm1Mjz/? Ret^tm1Ddg/Ret^tm1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J	MGI:4413446

Allelic Composition	Mrgprd^tm1Mjz/Mrgprd^tm1Mjz
Genetic Background	B6.129S1-Mrgprd^tm1Mjz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrgprd^tm1Mjz mutation (2 available); any Mrgprd mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyporesponsive to tactile stimuli ( J:150802 )

• following exposure to mechanical stimuli, mice exhibit decreased mean firing rates compared with wild-type mice

• however, mechanical threshold and peak instantaneous frequency are normal

increased thermal nociceptive threshold ( J:150802 )

• mice exhibit decreased cold and heat sensitivity compared with wild-type mice

• mice exhibit a lower cold threshold and a higher heat threshold compared with wild-type mice

• peak instant frequency is decreased under heat conditions compared to in wild-type mice

• in mice subjected to a heat ramp, average firing rate of neurons is decreased compared to in wild-type mice

nervous system

abnormal single cell response ( J:150802 )

• in mice subjected to a heat ramp, average firing rate of neurons is decreased compared to in wild-type mice

• patch clamp studies reveal a higher rheobase than in wild-type neurons

• beta-alanine has no effect on firing rate unlike in wild-type neurons

Allelic Composition	Mrgprd^tm1Mjz/Mrgprd^tm1Mjz
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrgprd^tm1Mjz mutation (2 available); any Mrgprd mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:94938 )

N	• mice are fertile

behavior/neurological

behavior/neurological phenotype ( J:94938 )

N	• mice exhibit no gross behavioral abnormalities

Allelic Composition	Mrgprd^tm1Mjz/Mrgprd^{tm2.1(Hbegf)Mjz}
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrgprd^tm1Mjz mutation (2 available); any Mrgprd mutation (24 available)
Mrgprd^{tm2.1(Hbegf)Mjz} mutation (0 available); any Mrgprd mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:149999 )

N	• behavioral responses to noxious heat and cold stimuli are normal

hyporesponsive to tactile stimuli ( J:149999 )

• diphtheria-treated mice exhibit double the threshold to paw withdrawal in response to calibrated von Frey filaments unlike similarly treated wild-type mice

• elevated response threshold following diphtheria treatment persists for at least 31 days

• diphtheria-treated mice exposed to capsaicin do not exhibit any further decrease in mechanosensitivity

abnormal nociception after inflammation ( J:149999 )

• diphtheria-treated mice exposed to complete Freund's adjuvant exhibit higher mechanical nociception threshold compared to in similarly treated wild-type mice

nervous system

abnormal neuron morphology ( J:149999 )

• treatment with diphtheria toxin results in a greater than 98% ablation of Mrgprd+ cell bodies in the dorsal root ganglion and in central and peripheral fibers

Allelic Composition	Mrgprd^tm1Mjz/Mrgprd^tm3(DTA)Mjz
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrgprd^tm1Mjz mutation (2 available); any Mrgprd mutation (24 available)
Mrgprd^tm3(DTA)Mjz mutation (0 available); any Mrgprd mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:149999 )

N	• mice exhibit normal sensitivity to mechanical and thermal stimuli

Allelic Composition	Mrgprd^tm1Mjz/? Ret^tm1Ddg/Ret^tm1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Mrgprd^tm1Mjz mutation (2 available); any Mrgprd mutation (24 available)
Ret^tm1Ddg mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neurite morphology ( J:126484 )

• at P14, GFP+ skin neuron projections are reduced and punctate unlike in control Mrgprd^tm1Mjz Ret^tm1Ddg homozygotes

• however, central axonal projections in the thoracic spinal cord exhibit normal lamina specific innervation of peptidergic and nonpectidergic projections

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