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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fosl2tm2Wag
targeted mutation 2, Erwin F Wagner
MGI:3521818
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fosl2tm2Wag/Fosl2tm2Wag
Meox2tm1(cre)Sor/Meox2+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:4834996
cn2
 		Fosl2tm2Wag/Fosl2tm2Wag
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4834995
cn3
 		Fosl2tm2Wag/Fosl2tm2Wag
Tg(COL2A1-cre)1Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3522178
cn4
 		Fosl2tm2Wag/Fosl2tm2Wag
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:5586500


Genotype
MGI:4834996
cn1
Allelic
Composition		 Fosl2tm2Wag/Fosl2tm2Wag
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm2Wag mutation (0 available); any Fosl2 mutation (13 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:137646 )
N
• osteoclasts are normal




Genotype
MGI:4834995
cn2
Allelic
Composition		 Fosl2tm2Wag/Fosl2tm2Wag
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm2Wag mutation (0 available); any Fosl2 mutation (13 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal osteoclast differentiation ( J:137646 )
• differentiation and fusion of osteoclast progenitors is abnormal

immune system
abnormal osteoclast differentiation ( J:137646 )
• differentiation and fusion of osteoclast progenitors is abnormal

skeleton
abnormal osteoclast differentiation ( J:137646 )
• differentiation and fusion of osteoclast progenitors is abnormal

cellular
abnormal osteoclast differentiation ( J:137646 )
• differentiation and fusion of osteoclast progenitors is abnormal




Genotype
MGI:3522178
cn3
Allelic
Composition		 Fosl2tm2Wag/Fosl2tm2Wag
Tg(COL2A1-cre)1Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm2Wag mutation (0 available); any Fosl2 mutation (13 available)
Tg(COL2A1-cre)1Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:94393 )
• died between P10 and P25

growth/size/body
decreased body size ( J:94393 )
decreased body weight ( J:94393 )
postnatal growth retardation ( J:94393 )
• growth retardation after P1

skeleton
decreased width of hypertrophic chondrocyte zone ( J:94393 )
• narrower zone of hypertrophic chondrocytes in P5-P23 femoral growth plates
kyphosis ( J:94393 )
• developed kyphosis between P5 and P10
abnormal chondrocyte morphology ( J:94393 )
• reduced zone of proliferating chondrocytes in femoral growth plates at P23 but not at P5 or P10
decreased bone mineralization ( J:94393 )
• smaller mineralized regions in long bones




Genotype
MGI:5586500
cn4
Allelic
Composition		 Fosl2tm2Wag/Fosl2tm2Wag
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm2Wag mutation (0 available); any Fosl2 mutation (13 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoblast physiology ( J:211215 )
• fewer mineralized nodules produced from primary osteoblasts under osteogenic conditions
abnormal osteoclast morphology ( J:211215 )
• increased osteoclast surface
abnormal osteoblast morphology ( J:211215 )
• decreased osteoblast surface
decreased bone ossification ( J:211215 )
• decreased bone formation

cellular
abnormal osteoblast physiology ( J:211215 )
• fewer mineralized nodules produced from primary osteoblasts under osteogenic conditions

homeostasis/metabolism
decreased circulating glucose level ( J:211215 )
• in mice fed a high fat diet
• however, levels are normal in mice fed a normal diet
impaired glucose tolerance ( J:211215 )
• in mice fed a normal diet and high fat diet
insulin resistance ( J:211215 )
• in mice fed a high fat diet
• however, mice fed a normal diet exhibit insulin tolerance

growth/size/body
increased body weight ( J:211215 )
• under normal diet and high fat diet

adipose tissue
adipose tissue phenotype ( J:211215 )
N
• mice exhibit normal adipocyte number and size
increased gonadal fat pad weight ( J:211215 )
• under normal diet and high fat diet

hematopoietic system
abnormal osteoclast morphology ( J:211215 )
• increased osteoclast surface

immune system
abnormal osteoclast morphology ( J:211215 )
• increased osteoclast surface




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory