All Phenotypes Pdk2<tm1Rhar> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pdk2^tm1Rhar
targeted mutation 1, Robert A Harris
MGI:3521813

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdk2^tm1Rhar/Pdk2^tm1Rhar	B6.129-Pdk2^tm1Rhar	MGI:5009224
cn2	Pdk1^{tm1c(EUCOMM)Hmgu}/Pdk1^{tm1c(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar Tg(Prrx1-cre)1Cjt/0	involves: 129 * C57BL/6J * C57BL/6N * SJL/J	MGI:6712414
cn3	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6712415
cx4	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar	involves: 129 * C57BL/6J * C57BL/6N	MGI:6712416
cx5	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk4^tm1Rhar/Pdk4^tm1Rhar	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6712269

Allelic Composition	Pdk2^tm1Rhar/Pdk2^tm1Rhar
Genetic Background	B6.129-Pdk2^tm1Rhar

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

impaired skeletal muscle contractility ( J:172411 )

• at 40 Hz, muscle force is lower than in wild-type muscle

Allelic Composition	Pdk1^{tm1c(EUCOMM)Hmgu}/Pdk1^{tm1c(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129 * C57BL/6J * C57BL/6N * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (27 available)
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (22 available)
Pdk3^em1Eze mutation (0 available); any Pdk3 mutation (7 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (31 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

N	• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

N	• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

N	• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar
Genetic Background	involves: 129 * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (27 available)
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (22 available)
Pdk3^em1Eze mutation (0 available); any Pdk3 mutation (7 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:303714 )

• mice die between P0 and P4

homeostasis/metabolism

decreased circulating glucose level ( J:303714 )

• at P1, but not E18.5

increased circulating ketone body level ( J:303714 )

• increased serum 3-beta-hydroxybutyrate levels at P1, but not E18.5

decreased circulating lactate level ( J:303714 )

abnormal circulating protein level ( J:303714 )

• decreased pyruvate and lactate serum levels

skeleton

skeleton phenotype ( J:303714 )

N	• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk4^tm1Rhar/Pdk4^tm1Rhar
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (27 available)
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (22 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

• mice exhibit normal embryonic bone development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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