Pdk1^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Pdk1^{tm1c(EUCOMM)Hmgu}
• Name: pyruvate dehydrogenase kinase, isoenzyme 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6711987
• Gene: Pdk1 Location: Chr2:71703568-71734202 bp, + strand Genetic Position: Chr2, 42.84 cM
• Alliance: Pdk1^{tm1c(EUCOMM)Hmgu} page
• IMPC: Pdk1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303714
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdk1 Mutation: 28 strains or lines available

References

• Original: J:303714 Heinemann-Yerushalmi L, et al., BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development. Dev Cell. 2021 Mar 23
• All: 1 reference(s)