All Phenotypes Pdk4<tm1Rhar> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdk4^tm1Rhar/Pdk4^tm1Rhar	B6.129-Pdk4^tm1Rhar	MGI:3697306
cn2	Pdk1^{tm1c(EUCOMM)Hmgu}/Pdk1^{tm1c(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar Tg(Prrx1-cre)1Cjt/0	involves: 129 * C57BL/6J * C57BL/6N * SJL/J	MGI:6712414
cx3	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar	involves: 129 * C57BL/6J * C57BL/6N	MGI:6712416
cx4	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk4^tm1Rhar/Pdk4^tm1Rhar	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6712269
cx5	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk4^tm1Rhar/Pdk4^tm1Rhar	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6712417

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:115895 )

• lower serum concentration of pyruvate in mice fasted for 48 h compared to wild-type mice

abnormal circulating amino acid level ( J:115895 )

• higher serum concentration of branched chain amino acids in mice fasted for 48 h compared to wild-type mice

decreased circulating alanine level ( J:115895 )

• lower serum concentration of alanine in mice fasted for 48 h compared to wild-type mice

decreased circulating lactate level ( J:115895 )

• lower serum concentration of lactate in mice fasted for 48 h compared to wild-type mice

increased circulating free fatty acids level ( J:115895 )

• higher serum concentration of non-esterified fatty acids in mice fasted for 48 h compared to wild-type mice

abnormal glucose homeostasis ( J:115895 )

• after 48 h of starvation, livers contain 42% less free glucose compared to similarly starved wild-type mice

• glucose oxidation rate is 36% greater in diaphragms; however, lactase release and net glycolysis rates are reduced by 37% and 35%, respectively

decreased circulating glucose level ( J:115895 )

• 30% and 58% lower in 24 h and 48 h fasted mice, respectively, compared to similarly fasted wild-type mice

• however, in the fed state blood glucose levels are similar to wild-type

increased circulating insulin level ( J:115895 )

• small but significant increase in insulin levels after 48 h of starvation compared to wild-type mice

improved glucose tolerance ( J:115895 )

• slight but significant increase in glucose tolerance

• however, no difference is seen in insulin sensitivity

decreased liver glycogen level ( J:115895 )

• larger decrease in liver glycogen levels induced by 24 h of starvation and a smaller rebound in levels between 24 and 48 h of starvation compared to wild-type mice

• however, the starvation-induced reduction in skeletal muscle glycogen is similar to wild-type

abnormal glycerol level ( J:115895 )

• higher serum concentration of triacylglycerol in mice fasted for 48 h compared to wild-type mice

ketosis ( J:115895 )

• ketone body levels are elevated in the liver after 48 h of starvation

increased circulating ketone body level ( J:115895 )

• higher serum concentration of acetoacetate and beta-hydroxybutyrate in mice fasted for 48 h compared to wild-type mice

liver/biliary system

decreased liver glycogen level ( J:115895 )

• larger decrease in liver glycogen levels induced by 24 h of starvation and a smaller rebound in levels between 24 and 48 h of starvation compared to wild-type mice

• however, the starvation-induced reduction in skeletal muscle glycogen is similar to wild-type

Allelic Composition	Pdk1^{tm1c(EUCOMM)Hmgu}/Pdk1^{tm1c(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129 * C57BL/6J * C57BL/6N * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (28 available)
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (23 available)
Pdk3^em1Eze mutation (0 available); any Pdk3 mutation (8 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (30 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

N	• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

N	• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

N	• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk3^em1Eze/Pdk3^em1Eze Pdk4^tm1Rhar/Pdk4^tm1Rhar
Genetic Background	involves: 129 * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (28 available)
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (23 available)
Pdk3^em1Eze mutation (0 available); any Pdk3 mutation (8 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:303714 )

• mice die between P0 and P4

homeostasis/metabolism

decreased circulating glucose level ( J:303714 )

• at P1, but not E18.5

increased circulating ketone body level ( J:303714 )

• increased serum 3-beta-hydroxybutyrate levels at P1, but not E18.5

decreased circulating lactate level ( J:303714 )

abnormal circulating protein level ( J:303714 )

• decreased pyruvate and lactate serum levels

skeleton

skeleton phenotype ( J:303714 )

N	• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk2^tm1Rhar/Pdk2^tm1Rhar Pdk4^tm1Rhar/Pdk4^tm1Rhar
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (28 available)
Pdk2^tm1Rhar mutation (1 available); any Pdk2 mutation (23 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

• mice exhibit normal embryonic bone development

Allelic Composition	Pdk1^{tm1a(EUCOMM)Hmgu}/Pdk1^{tm1a(EUCOMM)Hmgu} Pdk4^tm1Rhar/Pdk4^tm1Rhar
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Pdk1 mutation (28 available)
Pdk4^tm1Rhar mutation (1 available); any Pdk4 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:303714 )

• mice are viable

reproductive system

reproductive system phenotype ( J:303714 )

• mice are fertile

skeleton

skeleton phenotype ( J:303714 )

• mice exhibit normal embryonic bone development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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