All Phenotypes Golga3<repro27> MGI Mouse

reproductive system phenotype ( J:199215 )

N	• female mice exhibit normal fertility

decreased male germ cell number ( J:199215 )

• by P18

abnormal male germ cell apoptosis ( J:199215 )

asthenozoospermia ( J:92463 , J:199215 )

• low epididymal sperm motility and no IVF success (J:92463)

• negligible motility in few collected spermatozoa (J:199215)

abnormal testis morphology ( J:199215 )

• vacuolized and enlarged lumens at P18

• however, testes weight is normal

decreased testis weight ( J:92463 )

• low testis weight

abnormal spermatogenesis ( J:199215 )

• delayed timing with delayed appearance of round and elongating spermatids

azoospermia ( J:199215 )

• absence of round spermatids at P21

oligozoospermia ( J:92463 )

• very low epididymal sperm concentration

teratozoospermia ( J:199215 )

• abnormally shaped heads, tails without heads and heads without tails

absent sperm flagellum ( J:92463 )

• some sperm with no tails

detached sperm flagellum ( J:199215 )

abnormal sperm head morphology ( J:199215 )

globozoospermia ( J:92463 )

• abnormally shaped sperm heads

abnormal spermiogenesis ( J:199215 )

• in the few surviving germ cells with paired nuclei during acrosome development, disorganized Golgi complex, abnormal distribution of condensing chromatin, vacuolization in nuclei, mislocalization of mitochondria and vacuolization around the spermatid head region

male infertility ( J:92463 , J:199215 )

(J:92463)

(J:199215)

impaired fertilization ( J:199215 )

• sperm fertilized 0 of 65 oocytes in an in vitro fertilization assay

decreased fertilization frequency ( J:199215 )