All Phenotypes Akap9<repro12> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akap9^repro12
reproductive mutant 12, JAX Reproductive Mutagenesis Program
MGI:3512933

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akap9^repro12/Akap9^repro12	involves: C3HeB/FeJ * C57BL/6J	MGI:3513136
hm2	Akap9^repro12/Akap9^repro12	involves: C57BL/6J	MGI:5516020
ht3	Akap9^mei2-5/Akap9^repro12	involves: 129S1/Sv * C57BL/6J	MGI:5516021
ht4	Akap9^repro12/Akap9^{tm1b(KOMP)Wtsi}	involves: C57BL/6J * C57BL/6N * FVB/N	MGI:5516022

Allelic Composition	Akap9^repro12/Akap9^repro12
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9^repro12 mutation (0 available); any Akap9 mutation (180 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased seminal vesicle weight ( J:92463 )

• low seminal vesicle weight

abnormal seminiferous tubule morphology ( J:92463 )

• few elongated spermatids and abnormal round cells with condensed nuclei in many tubules

decreased testis weight ( J:92463 )

• low testis weight

reproductive system

oligozoospermia ( J:92463 )

• generally no epididymal sperm recovered

globozoospermia ( J:92463 )

• among sperm recovered, there is high frequency of morphological head abnormalities and low IVF success

decreased seminal vesicle weight ( J:92463 )

• low seminal vesicle weight

abnormal seminiferous tubule morphology ( J:92463 )

• few elongated spermatids and abnormal round cells with condensed nuclei in many tubules

decreased testis weight ( J:92463 )

• low testis weight

male infertility ( J:92463 )

cellular

oligozoospermia ( J:92463 )

• generally no epididymal sperm recovered

globozoospermia ( J:92463 )

• among sperm recovered, there is high frequency of morphological head abnormalities and low IVF success

Allelic Composition	Akap9^repro12/Akap9^repro12
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9^repro12 mutation (0 available); any Akap9 mutation (180 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of spermatogenesis ( J:198499 )

• germ cells in stage XII tubules do not progress beyond zygonema

Allelic Composition	Akap9^mei2-5/Akap9^repro12
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9^mei2-5 mutation (0 available); any Akap9 mutation (180 available)
Akap9^repro12 mutation (0 available); any Akap9 mutation (180 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatogenesis ( J:198499 )

• severely impaired

azoospermia ( J:198499 )

• devoid of mature spermatozoa

arrest of spermatogenesis ( J:198499 )

• no evidence of spermiogenesis

• mice are phenotypically indistinguishable from either single homozygote

cellular

azoospermia ( J:198499 )

• devoid of mature spermatozoa

Allelic Composition	Akap9^repro12/Akap9^{tm1b(KOMP)Wtsi}
Genetic Background	involves: C57BL/6J * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9^repro12 mutation (0 available); any Akap9 mutation (180 available)
Akap9^{tm1b(KOMP)Wtsi} mutation (0 available); any Akap9 mutation (180 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatogenesis ( J:198499 )

• severely impaired

azoospermia ( J:198499 )

• devoid of mature spermatozoa

cellular

azoospermia ( J:198499 )

• devoid of mature spermatozoa

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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