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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif4g3repro8
reproductive mutant 8, JAX Reproductive Mutagenesis Program
MGI:3512906
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eif4g3repro8/Eif4g3repro8 C3Fe.B6-Eif4g3repro8/Hand MGI:6272327
hm2
 		Eif4g3repro8/Eif4g3repro8 involves: C3HeB/FeJ * C57BL/6J MGI:4443306
ht3
 		Eif4g3Gt(XC431)Byg/Eif4g3repro8 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J MGI:4443308


Genotype
MGI:6272327
hm1
Allelic
Composition		 Eif4g3repro8/Eif4g3repro8
Genetic
Background		 C3Fe.B6-Eif4g3repro8/Hand
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4g3repro8 mutation (0 available); any Eif4g3 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of male meiosis ( J:256976 )
• although the mutant protein still localizes normally to the XY body in meiotic prophase spermatocytes, there is meiotic arrest specific to male gametes

cellular
arrest of male meiosis ( J:256976 )
• although the mutant protein still localizes normally to the XY body in meiotic prophase spermatocytes, there is meiotic arrest specific to male gametes




Genotype
MGI:4443306
hm2
Allelic
Composition		 Eif4g3repro8/Eif4g3repro8
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4g3repro8 mutation (0 available); any Eif4g3 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of male meiosis ( J:159444 )
• in meiotic prophase after mid-pachytene stage
• however, recombination and meiotic chromosome synapsis are normal
increased male germ cell apoptosis ( J:159444 )
• slight at P14 but greater at P17
decreased testis weight ( J:159444 )
• by one third

endocrine/exocrine glands
decreased testis weight ( J:159444 )
• by one third

cellular
arrest of male meiosis ( J:159444 )
• in meiotic prophase after mid-pachytene stage
• however, recombination and meiotic chromosome synapsis are normal
increased male germ cell apoptosis ( J:159444 )
• slight at P14 but greater at P17




Genotype
MGI:4443308
ht3
Allelic
Composition		 Eif4g3Gt(XC431)Byg/Eif4g3repro8
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4g3Gt(XC431)Byg mutation (0 available); any Eif4g3 mutation (106 available)
Eif4g3repro8 mutation (0 available); any Eif4g3 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of male meiosis ( J:159444 )
• no post-meiotic spermatid are produced unlike in wild-type mice

cellular
arrest of male meiosis ( J:159444 )
• no post-meiotic spermatid are produced unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory