Analysis Tools
normal phenotype
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• homozygotes are viable with no obvious abnormalities
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Allele Symbol Allele Name Allele ID |
Smad2tm1.1Mwst targeted mutation 1.1, Michael Weinstein MGI:3512448 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are viable with no obvious abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants are viable with no obvious abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice
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• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice
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• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice
• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice
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• at 3 months, fewer antral follicles are present compared to in wild-type ovaries
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• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries
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• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes
• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells
• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells
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• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice
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• at 8 months
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• at 8 months
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• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice
|
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• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice
• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice
|
|
|
• at 3 months, fewer antral follicles are present compared to in wild-type ovaries
|
|
|
• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries
|
|
|
• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes
• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells
• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells
|
|
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• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal reproductive morphology and physiology
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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