All Phenotypes Smad2<tm1Mwst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smad2^tm1Mwst
targeted mutation 1, Michael Weinstein
MGI:3512447

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad2^tm1Mwst/Smad2^tm1Mwst	involves: 129S6/SvEvTac * Black Swiss	MGI:3513601
ht2	Smad2^tm1Mwst/Smad2^tm1.2Mwst	involves: 129S6/SvEvTac * Black Swiss	MGI:3513602
ht3	Smad2^tm1Cxd/Smad2^tm1Mwst	involves: 129S6/SvEvTac * Black Swiss	MGI:3513603

Allelic Composition	Smad2^tm1Mwst/Smad2^tm1Mwst
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2^tm1Mwst mutation (0 available); any Smad2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94232 )

• homozygotes are viable with no obvious abnormalities

Allelic Composition	Smad2^tm1Mwst/Smad2^tm1.2Mwst
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2^tm1.2Mwst mutation (0 available); any Smad2 mutation (50 available)
Smad2^tm1Mwst mutation (0 available); any Smad2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94232 )

• homozygous embryos die before E11.5

embryo

abnormal developmental patterning ( J:94232 )

• three classes of mutant embryos are seen, those consisting of an empty yolk sac, those that have a mass of tissue attached to the distal tip of the yolk sac, and those that have severe midline defects

Allelic Composition	Smad2^tm1Cxd/Smad2^tm1Mwst
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2^tm1Cxd mutation (0 available); any Smad2 mutation (50 available)
Smad2^tm1Mwst mutation (0 available); any Smad2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:94232 )

• homozygous embryos die before E11.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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