Phenotypes associated with this allele

• Allele Symbol: Slamf1^tm1Vei
• Allele Name: targeted mutation 1, Andre Veillette
• Allele ID: MGI:3512183
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slamf1^tm1Vei/Slamf1^tm1Vei	involves: 129 * C57BL/6	MGI:3809397

Genotype
MGI:3809397

hm1

• Allelic Composition: Slamf1^tm1Vei/Slamf1^tm1Vei
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:133047 )

N • mice do not show excessive T cell expansion, defects in cytokine production, control and clearance of LCMV by CD8 T cells, germinal center formation and long term humoral immunity

abnormal CD4-positive, alpha-beta T cell physiology ( J:93886 , J:133047 )

• cells exhibit impaired IL-4 and IL-13 production upon stimulation with anti-CD3, anti-CD3 and anti-CD28 or PMA plus ionomycin (J:93886)

• proliferation is not impaired and Ifng production is relatively normal (J:93886)

• trend of lower effector CD4 T cell responses to LCMV and np309 epitope is detected (J:133047)

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:93886 , J:133047 )

• cells exhibit impaired IL-4 and IL-13 production upon stimulation with anti-CD3, anti-CD3 and anti-CD28 or PMA plus ionomycin (J:93886)

• proliferation is not impaired and Ifng production is relatively normal (J:93886)

• trend of lower effector CD4 T cell responses to LCMV and np309 epitope is detected (J:133047)