Phenotypes associated with this allele

• Allele Symbol: Pla2g10^Gt712Lex
• Allele Name: gene trap 712, Lexicon Genetics
• Allele ID: MGI:3512106
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g10^Gt712Lex/Pla2g10^Gt712Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3775794

Genotype
MGI:3775794

hm1

• Allelic Composition: Pla2g10^Gt712Lex/Pla2g10^Gt712Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased eosinophil cell number ( J:125607 )

• following exposure to ovalbumin, mice exhibit decreased eosinophil cell numbers in bronchoalveolar lavage compared to wild-type mice

decreased T cell number ( J:125607 )

• at day 29 of ovalbumin exposure in bronchoalveolar lavage fluid

decreased CD4-positive, alpha-beta T cell number ( J:125607 )

• at day 29 of ovalbumin exposure in bronchoalveolar lavage fluid

decreased CD8-positive, alpha-beta T cell number ( J:125607 )

• at day 29 of ovalbumin exposure in bronchoalveolar lavage fluid

decreased IgE level ( J:125607 )

• at day 29 of ovalbumin exposure

abnormal interleukin level ( J:125607 )

• at day 76 of ovalbumin exposure or induction of an acute asthma model, no IL-4 and reduced levels of IL-5 and IL-13 proteins are found in the bronchoalveolar lavage fluid

• however, interleukin response to antigenic stimulation is normal

decreased inflammatory response ( J:125607 )

• following exposure to ovalbumin, mice exhibit decreased total inflammatory cells and eosinophils, goblet cell metaplasia/mucus hypersecretion, and edema of airway interstitium compared to wild-type mice

• at day 76 of exposure to ovalbumin, allergen-induced increased smooth muscle cell layer mass and subepithelial fibrosis is decreased compared to in wild-type mice

• however, mice respond normally to methacholine

• at day 76 of exposure to ovalbumin, mice do not produce increased levels of PGE2, PGD2, LTB, or cysLTs as in wild-type mice indicating an impaired eicosanoid release

hematopoietic system

decreased eosinophil cell number ( J:125607 )

• following exposure to ovalbumin, mice exhibit decreased eosinophil cell numbers in bronchoalveolar lavage compared to wild-type mice

decreased T cell number ( J:125607 )

• at day 29 of ovalbumin exposure in bronchoalveolar lavage fluid

decreased CD4-positive, alpha-beta T cell number ( J:125607 )

• at day 29 of ovalbumin exposure in bronchoalveolar lavage fluid

decreased CD8-positive, alpha-beta T cell number ( J:125607 )

• at day 29 of ovalbumin exposure in bronchoalveolar lavage fluid

decreased IgE level ( J:125607 )

• at day 29 of ovalbumin exposure

homeostasis/metabolism

abnormal prostaglandin level ( J:125607 )

• at day 76 of exposure to ovalbumin, mice do not produce increased levels of PGE2 or PGD2 as in wild-type mice

abnormal interleukin level ( J:125607 )

• at day 76 of ovalbumin exposure or induction of an acute asthma model, no IL-4 and reduced levels of IL-5 and IL-13 proteins are found in the bronchoalveolar lavage fluid

• however, interleukin response to antigenic stimulation is normal