Phenotypes associated with this allele

• Allele Symbol: Slc39a3^tm1Gka
• Allele Name: targeted mutation 1, Glen K Andrews
• Allele ID: MGI:3512105
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc39a3^tm1Gka/Slc39a3^tm1Gka	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3582300

Genotype
MGI:3582300

hm1

• Allelic Composition: Slc39a3^tm1Gka/Slc39a3^tm1Gka
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased double-positive T cell number ( J:99161 )

• loss of pre-T cells was significantly accentuated over that seen in wild-type when fed a zinc-deficient diet

increased CD4-positive, alpha-beta T cell number ( J:99161 )

• increase of helper T cells was accentuated over that seen in wild-type when fed a zinc-deficient diet

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:99161 )

• increase of cytolytic T cells was accentuated over that seen in wild-type when fed a zinc-deficient diet

hematopoietic system

decreased double-positive T cell number ( J:99161 )

• loss of pre-T cells was significantly accentuated over that seen in wild-type when fed a zinc-deficient diet

increased CD4-positive, alpha-beta T cell number ( J:99161 )

• increase of helper T cells was accentuated over that seen in wild-type when fed a zinc-deficient diet

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:99161 )

• increase of cytolytic T cells was accentuated over that seen in wild-type when fed a zinc-deficient diet

cellular

maternal effect ( J:99161 )

• homozygous females fed a zinc-deficient diet beginning on day 8 of pregnancy, showed a small increase in the percentage of abnormal embryos and this effect was exacerbated if the embryos also lacked Slc39a3