Slc39a3^tm1Gka
Targeted Allele Detail

Summary

• Symbol: Slc39a3^tm1Gka
• Name: solute carrier family 39 (zinc transporter), member 3; targeted mutation 1, Glen K Andrews
• MGI ID: MGI:3512105
• Synonyms: ZIP3^-
• Gene: Slc39a3 Location: Chr10:80864374-80873169 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Slc39a3^tm1Gka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99161
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene following the translation initiating ATG has been deleted and replaced by an EGFP open reading frame followed by a loxP-flanked neomycin selection cassette. Expression of EGFP is driven by the endogenous promoter. (J:99161)

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc39a3 Mutation: 11 strains or lines available

Notes

Double mutant subjects were day E14 embryos from matings of mice homozygous for both mutations whose dams were fed a zinc-deficient diet from day 8 of pregnancy.

References

• Original: J:99161 Dufner-Beattie J, et al., Generation and Characterization of Mice Lacking the Zinc Uptake Transporter ZIP3. Mol Cell Biol. 2005 Jul;25(13):5607-15
• All: 4 reference(s)