Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nrp1tm2.1Ddg targeted mutation 2.1, David D Ginty MGI:3512103 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• distal axons of the ophthalmic nerve were more defasciculated and disorganized than those in Nrp1tm1Ddg
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• spinal nerves were disorganized in E11.5 mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mid-to-late embryonic lethality
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• systemic vascular deficiencies at E12.5 such as distended vessels in the abdominal wall
• brain vessels were large and underdeveloped
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• lack of medium and small-diameter branched vessels in the abdominal wall and brain vessels were not branched
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• exhibited bilateral atrial enlargement
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• in the olfactory bulb, Grueneberg glomeruli formation is not affected and their exclusion from guanylate cyclase G (GC-G) glomeruli is not affected
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• numbers of Grueneberg axonal bundles consisting of multiple axons do not avoid the accessory olfactory bulb as seen in control animals; axonal fibers and microglomeruli cross bulb from medial to lateral side
• some Grueneberg fibers end deep into the vomeronasal glomeruli primarily in rostral part (not seen in controls)
• Grueneberg glomeruli form normally in mice with specific Nrp2 deletion and Grueneberg axons lacking Nrp2 do not cross the accessory olfactory bulb
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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