Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2.1Ddg mutation
(0 available);
any
Nrp1 mutation
(81 available)
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nervous system
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• distal axons of the ophthalmic nerve were more defasciculated and disorganized than those in Nrp1tm1Ddg
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• spinal nerves were disorganized in E11.5 mutants
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2.1Ddg mutation
(0 available);
any
Nrp1 mutation
(81 available)
Nrp1tm2Ddg mutation
(1 available);
any
Nrp1 mutation
(81 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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• mid-to-late embryonic lethality
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cardiovascular system
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• systemic vascular deficiencies at E12.5 such as distended vessels in the abdominal wall
• brain vessels were large and underdeveloped
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• lack of medium and small-diameter branched vessels in the abdominal wall and brain vessels were not branched
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• exhibited bilateral atrial enlargement
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2.1Ddg mutation
(0 available);
any
Nrp1 mutation
(81 available)
Nrp1tm2Ddg mutation
(1 available);
any
Nrp1 mutation
(81 available)
Tg(Gucy2g-cre,-EGFP)52Irod mutation
(0 available)
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nervous system
N |
• in the olfactory bulb, Grueneberg glomeruli formation is not affected and their exclusion from guanylate cyclase G (GC-G) glomeruli is not affected
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• numbers of Grueneberg axonal bundles consisting of multiple axons do not avoid the accessory olfactory bulb as seen in control animals; axonal fibers and microglomeruli cross bulb from medial to lateral side
• some Grueneberg fibers end deep into the vomeronasal glomeruli primarily in rostral part (not seen in controls)
• Grueneberg glomeruli form normally in mice with specific Nrp2 deletion and Grueneberg axons lacking Nrp2 do not cross the accessory olfactory bulb
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