Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2.1Ddg mutation
(0 available);
any
Nrp1 mutation
(81 available)
Nrp1tm2Ddg mutation
(1 available);
any
Nrp1 mutation
(81 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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• mid-to-late embryonic lethality
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cardiovascular system
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• systemic vascular deficiencies at E12.5 such as distended vessels in the abdominal wall
• brain vessels were large and underdeveloped
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• lack of medium and small-diameter branched vessels in the abdominal wall and brain vessels were not branched
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• exhibited bilateral atrial enlargement
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2Ddg mutation
(1 available);
any
Nrp1 mutation
(81 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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• 25/25 mutant mice died perinatally
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cardiovascular system
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• exhibit multiple cardiac defects
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• misplacement of coronary arteries
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2Ddg mutation
(1 available);
any
Nrp1 mutation
(81 available)
Nrp2tm1Ddg mutation
(0 available);
any
Nrp2 mutation
(88 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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cardiovascular system
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N |
• no major abnormalities in limb vascular patterning are detected at E13.5
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nervous system
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• olfactory sensory neurons expressing the null allele of Nrp1 have an altered and variable pattern of glomeruli formation in the olfactory bulb, including ectopic glomeruli, but the labeled glomeruli do not show an anterior shift relative to Nrp1 wild type controls
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nervous system
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• reduced gonadotropin-releasing hormone neurons
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cardiovascular system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm2.1Ddg mutation
(0 available);
any
Nrp1 mutation
(81 available)
Nrp1tm2Ddg mutation
(1 available);
any
Nrp1 mutation
(81 available)
Tg(Gucy2g-cre,-EGFP)52Irod mutation
(0 available)
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nervous system
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N |
• in the olfactory bulb, Grueneberg glomeruli formation is not affected and their exclusion from guanylate cyclase G (GC-G) glomeruli is not affected
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• numbers of Grueneberg axonal bundles consisting of multiple axons do not avoid the accessory olfactory bulb as seen in control animals; axonal fibers and microglomeruli cross bulb from medial to lateral side
• some Grueneberg fibers end deep into the vomeronasal glomeruli primarily in rostral part (not seen in controls)
• Grueneberg glomeruli form normally in mice with specific Nrp2 deletion and Grueneberg axons lacking Nrp2 do not cross the accessory olfactory bulb
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Analysis Tools