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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Frem1+
wild type
MGI:3511267
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Frem1bat/Frem1+ C57BL/6J-Frem1bat MGI:5295995
ht2
 		Frem1tm1Ksek/Frem1+ involves: 129 * C57BL/6 MGI:5296001


Genotype
MGI:5295995
ht1
Allelic
Composition		 Frem1bat/Frem1+
Genetic
Background		 C57BL/6J-Frem1bat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem1bat mutation (2 available); any Frem1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal cranial suture morphology ( J:177282 )
• 42% of heterozygotes exhibit variable sutural abnormalities, including complete fusion, sutural asymmetry and advanced endocranial suture fusion
asymmetric snout ( J:177282 )
• 2 of 21 mutants exhibit varying degrees of midfacial asymmetry and/or midface hypoplasia
short snout ( J:177282 )
• 2 of 21 mutants exhibit varying degrees of midfacial asymmetry and/or midface hypoplasia

skeleton
abnormal cranial suture morphology ( J:177282 )
• 42% of heterozygotes exhibit variable sutural abnormalities, including complete fusion, sutural asymmetry and advanced endocranial suture fusion
premature metopic suture closure ( J:177282 )
• mutants exhibit anterofrontal cranial deformation similar to metopic craniosynostosis and trigonocephaly, although less severe than seen in homozygotes

growth/size/body
asymmetric snout ( J:177282 )
• 2 of 21 mutants exhibit varying degrees of midfacial asymmetry and/or midface hypoplasia
short snout ( J:177282 )
• 2 of 21 mutants exhibit varying degrees of midfacial asymmetry and/or midface hypoplasia
trigonocephaly ( J:177282 )

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chromosome 9p deletion syndrome DOID:0060732 OMIM:158170
 J:177282




Genotype
MGI:5296001
ht2
Allelic
Composition		 Frem1tm1Ksek/Frem1+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem1tm1Ksek mutation (1 available); any Frem1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal cranial suture morphology ( J:177282 )
• mutants exhibit variable suture abnormalities similar to Frem1bat heterozygotes

skeleton
abnormal cranial suture morphology ( J:177282 )
• mutants exhibit variable suture abnormalities similar to Frem1bat heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory