All Phenotypes Gcgr<tm1Mjch> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gcgr^tm1Mjch/Gcgr^tm1Mjch	involves: 129 * C57BL/6J * SJL	MGI:5566825
hm2	Gcgr^tm1Mjch/Gcgr^tm1Mjch	involves: 129/Sv * C57BL/6J * SJL	MGI:3513508
cx3	Gcgr^tm1Mjch/Gcgr^tm1Mjch Lepr^tm1Jke/Lepr^tm1Jke	involves: 129 * 129X1/SvJ * C57BL/6J * SJL	MGI:5620894
cx4	Gcgr^tm1Mjch/Gcgr^tm1Mjch Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg}	involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL	MGI:6120555

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased pancreatic alpha cell proliferation ( J:208604 )

• increased alpha-cell proliferation

endocrine/exocrine glands

increased pancreatic alpha cell proliferation ( J:208604 )

• increased alpha-cell proliferation

increased pancreatic alpha cell mass ( J:208604 )

• increased alpha-cell mass

increased pancreatic alpha cell number ( J:208604 )

• alpha-cell hyperplasia

increased pancreatic beta cell mass ( J:208604 )

• increased beta-cell mass is secondary to enlargement of the pancreas

increased pancreas weight ( J:208604 )

increased glucagon secretion ( J:208604 )

• in the pancreas

homeostasis/metabolism

increased glucagon secretion ( J:208604 )

• in the pancreas

decreased susceptibility to diet-induced obesity ( J:216393 )

• mice fed a 60% fat diet with 10% sucrose in the water do not exhibit an increase in body fat as seen in wild-type mice

increased circulating glucagon level ( J:208604 )

decreased circulating insulin level ( J:208604 )

• in fasted mice

decreased carbon dioxide production ( J:216393 )

• rate of carbon dioxide elimination (VCO2) is reduced in mice fed a normal diet

• however, VCO2 is not affected by the high-fat diet in mutants

decreased oxygen consumption ( J:216393 )

• maximal oxygen consumption (VO2) is reduced in mice fed a normal diet

• however, VO2 is not affected by the high-fat diet in mutants

improved glucose tolerance ( J:208604 )

increased insulin sensitivity ( J:208604 )

increased bile salt level ( J:208604 )

• of total levels in plasma

decreased susceptibility to diet-induced non-insulin dependent diabetes ( J:216393 )

• mice fed a 60% fat diet with 10% sucrose in the water do not exhibit an increase in body fat and no do not become hyperinsulinemic or hyperglycemic compared to wild-type mice on this diet

behavior/neurological

decreased food intake ( J:216393 )

• mice fed the high-fat diet consume about 25% less food than wild-type mice

decreased locomotor activity ( J:216393 )

• mice are half as active as wild-type mice on a normal, as well as high-fat, diet

• however, mice fed a high-fat diet exhibit no change in physical activity compared to mice fed a normal diet

growth/size/body

increased pancreas weight ( J:208604 )

decreased susceptibility to diet-induced obesity ( J:216393 )

• mice fed a 60% fat diet with 10% sucrose in the water do not exhibit an increase in body fat as seen in wild-type mice

Allelic Composition	Gcgr^tm1Mjch/Gcgr^tm1Mjch
Genetic Background	involves: 129/Sv * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcgr^tm1Mjch mutation (0 available); any Gcgr mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:81772 )

• incomplete penetrance

prenatal lethality, incomplete penetrance ( J:81772 )

• incomplete penetrance

adipose tissue

decreased brown adipose tissue amount ( J:81772 )

• decrease in interscapular brown fat pad weight

decreased total body fat amount ( J:81772 )

• 10% reduction in adipose mass

decreased gonadal fat pad weight ( J:81772 )

• peri-gonadal WAT decreased

decreased interscapular fat pad weight ( J:81772 )

• decrease in interscapular brown fat pad weight

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:251829 )

N	• pancreatic beta cell mass

abnormal pancreatic alpha cell morphology ( J:251829 )

• increased cell size compared to wild-type

increased pancreatic alpha cell number ( J:251829 )

pancreatic islet hyperplasia ( J:81772 , J:251829 )

• due to alpha cell and to a lesser extent delta cell proliferation (J:81772)

• pancreata 2- to 3.5-fold bigger at 6wks; enlargement of pancreas (J:81772)

• 2-fold increase per pancreas area compared to wild-type (J:251829)

growth/size/body

increased body mass index ( J:81772 )

• 10% increase in lean body mass

homeostasis/metabolism

abnormal circulating amino acid level ( J:251829 )

• increased in plasma

decreased circulating glucose level ( J:81772 )

• males 71.9+/-2.4% of wild-type tested throughout the day

hypoglycemia ( J:81772 , J:251829 )

• males that fasted for 24 hours tested 1.7 +/-0.1 mM verses 3.7 +/- 0.2 mM in control (J:81772)

increased circulating glucagon level ( J:81772 , J:251829 )

• glucagon levels 56- to 280-fold higher in ambient and fasting mice (J:81772)

decreased circulating insulin level ( J:251829 )

decreased circulating leptin level ( J:81772 )

• decreased by 40-59%

increased circulating LDL cholesterol level ( J:81772 )

• fed and ambient levels increased 1.6- to 3.3-fold

improved glucose tolerance ( J:81772 )

decreased triglyceride level ( J:81772 )

• decreased by 60% in females

reproductive system

decreased litter size ( J:81772 )

Allelic Composition	Gcgr^tm1Mjch/Gcgr^tm1Mjch Lepr^tm1Jke/Lepr^tm1Jke
Genetic Background	involves: 129 * 129X1/SvJ * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcgr^tm1Mjch mutation (0 available); any Gcgr mutation (5 available)
Lepr^tm1Jke mutation (2 available); any Lepr mutation (121 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:216393 )

• mice are obese but weight less than single Lepr homozygotes

• however, glucose and insulin levels are in the normal range

homeostasis/metabolism

increased liver triglyceride level ( J:216393 )

• increase in liver triacylglycerol levels but to a lower extent than in single Lepr homozygotes

liver/biliary system

increased liver triglyceride level ( J:216393 )

• increase in liver triacylglycerol levels but to a lower extent than in single Lepr homozygotes

Allelic Composition	Gcgr^tm1Mjch/Gcgr^tm1Mjch Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg}
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcgr^tm1Mjch mutation (0 available); any Gcgr mutation (5 available)
Slc38a5^{tm1(KOMP)Vlcg} mutation (1 available); any Slc38a5 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:251829 )

N	• pancreatic beta cell mass

abnormal pancreatic alpha cell morphology ( J:251829 )

• almost 50% reduced hyperplasia compared to Gcgr single knockout mice

• reduced cell size compared to Gcgr single knockout mice

pancreatic islet hyperplasia ( J:251829 )

• increase per pancreas area compared to wild-type, but lower increase than Gcgr single knockout mice

homeostasis/metabolism

abnormal circulating amino acid level ( J:251829 )

• increased in plasma

hypoglycemia ( J:251829 )

increased circulating glucagon level ( J:251829 )

decreased circulating insulin level ( J:251829 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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