All Phenotypes Nbn<tm1Md> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nbn^tm1Md
targeted mutation 1, Martin Digweed
MGI:3505755

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nbn^tm1Md/Nbn^tm1Zqw Tg(Mx1-cre)1Cgn/0	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA	MGI:3510438

Allelic Composition	Nbn^tm1Md/Nbn^tm1Zqw Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm1Md mutation (0 available); any Nbn mutation (59 available)
Nbn^tm1Zqw mutation (0 available); any Nbn mutation (59 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosome breakage ( J:93598 )

• recombined lymphocytes show increased chromosomal instability and cells in which cre mediated excision occurred are preferentially lost from the bone marrow, thymus, and spleen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Nijmegen breakage syndrome		DOID:7400	OMIM:251260	J:93598

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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