Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sncatm1Sud mutation
(1 available);
any
Snca mutation
(34 available)
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nervous system
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• no signs of Parkinsonism in mice up to ages beyond 1 year
• resistant to the lethal effects of MPTP and less paralysis at the highest doses
• at lower MPTP doses, dopamine losses about half what is seen in controls
• effects of metamphetamine were opposite, 47% decrease in dopamine as compared to a 25% decrease in controls
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mortality/aging
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• mice die suddenly within a few days after weaning (average lifespan ~23.8 days); even if mutants are left with the mother, survival is <30 days
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growth/size/body
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• at P8, triple mutants weigh less than their littermates and at P20 are ~50% of wild-type littermates
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nervous system
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• degenerating neurons are found in brain and spinal cord of mutants
• mice show accelerated degeneration relative to Dnajc5-null animals at 10 days of age
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nervous system
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• dopamine levels decreased by 18% in the striatum but metabolic levels are normal
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homeostasis/metabolism
mortality/aging
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• double mutants display intermediate lifespan with average length between that of Snca,Dnajc5 double-null mice and Dnajc5-null mice
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Analysis Tools