Analysis Tools
behavior/neurological
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• mice exhibit diminished locomotor activity response to amphetamine compared with wild-type mice
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• reduced
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• in an open field test
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• on a rotarod
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• in four-limb akinesia and negative geotaxis tests, mice exhibit severe retardation in the initiation of voluntary movement compared with wild-type mice
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• shuffling with reduced gait width
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nervous system
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• in dopaminergic neurons at E17.5 and P0
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• reduced in volume
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• at P14, mice exhibit a more pronounced deficit in the ventral tegmental area compared with wild-type mice
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• at P0 and throughout adulthood
• in the substantia nigra pars compacta and ventral tegmental area
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muscle
homeostasis/metabolism
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• in the striatum
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cellular
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• in dopaminergic neurons at E17.5 and P0
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