Phenotypes associated with this allele

• Allele Symbol: Tg(Tnfrsf4-cre)1Nik
• Allele Name: transgene insertion 1, Nigel Killeen
• Allele ID: MGI:3487294
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(DTA)Kio/Gt(ROSA)26Sor^+ Tg(Tnfrsf4-cre)1Nik/0	B6.129-Tnfrsf4^tm2(cre)Nik Gt(ROSA)26Sor^tm1(DTA)Kio	MGI:5529105
cn2	Gata3^tm1Jfz/Gata3^tm1Jfz Tg(Tnfrsf4-cre)1Nik/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3511355

Genotype
MGI:5529105

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Kio/Gt(ROSA)26Sor⁺; Tg(Tnfrsf4-cre)1Nik/0
• Genetic Background: B6.129-Tnfrsf4^tm2(cre)Nik Gt(ROSA)26Sor^tm1(DTA)Kio

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:203905 )

• in a small proportion of mice as early as weaning

postnatal growth retardation ( J:203905 )

• in a small proportion of mice as early as weaning

endocrine/exocrine glands

exocrine pancreas atrophy ( J:203905 )

• without inflammatory infiltrates in a small proportion of mice

digestive/alimentary system

exocrine pancreas atrophy ( J:203905 )

• without inflammatory infiltrates in a small proportion of mice

Genotype
MGI:3511355

cn2

• Allelic Composition: Gata3^tm1Jfz/Gata3^tm1Jfz; Tg(Tnfrsf4-cre)1Nik/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:93538 )

increased T-helper 1 cell number ( J:93538 )

• increased numbers of IFN-gamma producing cells in response to Nippostrongylus brasiliensis infection

decreased T-helper 2 cell number ( J:93538 )

• decreased numbers of Il-4 producing cells in response to Nippostrongylus brasiliensis infection

decreased IgE level ( J:93538 )

• very little IgE in the serum in response to Nippostrongylus brasiliensis infection

immune system

abnormal CD4-positive, alpha beta T cell morphology ( J:93538 )

increased T-helper 1 cell number ( J:93538 )

• increased numbers of IFN-gamma producing cells in response to Nippostrongylus brasiliensis infection

decreased T-helper 2 cell number ( J:93538 )

• decreased numbers of Il-4 producing cells in response to Nippostrongylus brasiliensis infection

decreased IgE level ( J:93538 )

• very little IgE in the serum in response to Nippostrongylus brasiliensis infection

increased susceptibility to parasitic infection ( J:93538 )

• failed to expel worms after Nippostrongylus brasiliensis infection