All Phenotypes Ereg<tm1Dwt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ereg^tm1Dwt
targeted mutation 1, David W Threadgill
MGI:3057313

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ereg^tm1Dwt/Ereg^tm1Dwt	129S6/SvEvTac-Ereg^tm1Dwt	MGI:3512135
cx2	Egfr^wa2/Egfr^wa2 Ereg^tm1Dwt/Ereg^tm1Dwt	involves: 129S6/SvEvTac	MGI:3512136
cx3	Egf^tm1Dle/Egf^tm1Dle Ereg^tm1Dwt/Ereg^tm1Dwt Tgfa^tm1Unc/Tgfa^tm1Unc	involves: 129S6/SvEvTac * C57BL/6J	MGI:3512137
cx4	Apc^Min/Apc⁺ Ereg^tm1Dwt/Ereg^tm1Dwt	involves: 129S6/SvEvTac * C57BL/6J	MGI:3512138

Allelic Composition	Ereg^tm1Dwt/Ereg^tm1Dwt
Genetic Background	129S6/SvEvTac-Ereg^tm1Dwt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ereg^tm1Dwt mutation (1 available); any Ereg mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:93327 )

• male homozygotes lose more weight following dextran sulfate sodium treatment compared to wild-type males

• without dextran sodium sulfate treatment no gross abnormalities were detected and liver regeneration following partial hepatectomy was normal

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:93327 )

• male homozygotes develop more severe intestinal damage following dextran sulfate sodium treatment

digestive/alimentary system

increased susceptibility to induced colitis ( J:93327 )

• male homozygotes develop more severe intestinal damage following dextran sulfate sodium treatment

immune system

increased susceptibility to induced colitis ( J:93327 )

• male homozygotes develop more severe intestinal damage following dextran sulfate sodium treatment

Allelic Composition	Egfr^wa2/Egfr^wa2 Ereg^tm1Dwt/Ereg^tm1Dwt
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (88 available)
Ereg^tm1Dwt mutation (1 available); any Ereg mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:93327 )

• no gross abnormalities were detected and liver regeneration following partial hepatectomy was normal

Allelic Composition	Egf^tm1Dle/Egf^tm1Dle Ereg^tm1Dwt/Ereg^tm1Dwt Tgfa^tm1Unc/Tgfa^tm1Unc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egf^tm1Dle mutation (2 available); any Egf mutation (55 available)
Ereg^tm1Dwt mutation (1 available); any Ereg mutation (18 available)
Tgfa^tm1Unc mutation (3 available); any Tgfa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

eyelids open at birth ( J:93327 )

• partial penetrance similar to that in Tgfa^tm1Unc single homozygotes

integument

waved hair ( J:93327 )

• similar to that in Tgfa^tm1Unc single homozygotes

Allelic Composition	Apc^Min/Apc⁺ Ereg^tm1Dwt/Ereg^tm1Dwt
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (151 available)
Ereg^tm1Dwt mutation (1 available); any Ereg mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:93327 )

• the number, average size, and location of intestinal polyps is similar to Apc^Min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:93327 )

• the number, average size, and location of intestinal polyps is similar to Apc^Min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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