All Phenotypes Tg(ABCG5/ABCG8)14-2Hobb MGI Mouse

abnormal feces lipid level ( J:78963 , J:100491 )

• feces sterol levels are 3-fold higher in males and 6-fold higher in females compared to in wild-type mice (J:78963)

• fecal sterol excretion is increased 2- to 3-fold compared to in wild-type mice (J:100491)

steatorrhea ( J:78963 )

• in female but not male mice

decreased intestinal cholesterol absorption ( J:78963 , J:100491 )

• 50% (J:78963)

• 40% (J:100491)

decreased circulating phytosterol level ( J:78963 , J:100491 )

• plasma sitosterol levels are decreased 64% and 79% in males and females, respectively, compared to in wild-type mice (J:78963)

• plasma levels of plant sterol and campesterol are reduced compared to in wild-type mice (J:78963)

• however, the plasma levels of lathosterol are normal (J:78963)

• plasma sitosterol and campesterol levels are decreased compared to in wild-type mice (J:100491)

abnormal cholesterol homeostasis ( J:78963 )

• cholesterol synthesis is increased 3-fold in the female duodenum, decreased in male jejunum and ileum, and decreased in the female ileum compared to in wild-type mice

• however, fatty acid synthesis is normal

decreased circulating cholesterol level ( J:78963 )

• in fasting female mice

decreased circulating HDL cholesterol level ( J:78963 )

• in fasting female mice

increased cholesterol level ( J:78963 )

• bile cholesterol levels are increased 5-fold in male mice and 7-fold in female mice compared to in wild-type mice

abnormal bile composition ( J:78963 , J:100491 )

• bile cholesterol levels are increased 5-fold in male mice and 7-fold in female mice compared to in wild-type mice (J:78963)

• bile cholesterol levels are increased compared to in wild-type mice (J:100491)

decreased susceptibility to diet-induced hepatic steatosis ( J:78963 )

• when fed a high fat diet