Phenotypes associated with this allele

• Allele Symbol: Tg(ABCG5/ABCG8)14-2Hobb
• Allele Name: transgene insertion 14-2, Helen H Hobbs
• Allele ID: MGI:3057161
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Abcb4^tm1Bor/Abcb4^tm1Bor Tg(ABCG5/ABCG8)14-2Hobb/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL	MGI:3840643
tg2	Tg(ABCG5/ABCG8)14-2Hobb/0	involves: C57BL/6J * SJL	MGI:3840616

Genotype
MGI:3840643

cx1

• Allelic Composition: Abcb4^tm1Bor/Abcb4^tm1Bor; Tg(ABCG5/ABCG8)14-2Hobb/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:100491 )

N • plasma sitosterol and campesterol levels are normal

decreased intestinal cholesterol absorption ( J:100491 )

increased circulating alanine transaminase level ( J:100491 )

increased circulating aspartate transaminase level ( J:100491 )

liver/biliary system

abnormal bile composition ( J:100491 )

• bile cholesterol levels are decreased compared to in wild-type mice

digestive/alimentary system

decreased intestinal cholesterol absorption ( J:100491 )

abnormal feces composition ( J:100491 )

• fecal acidic sterol levels are decreased 30% compared to in wild-type mice

Genotype
MGI:3840616

tg2

• Allelic Composition: Tg(ABCG5/ABCG8)14-2Hobb/0
• Genetic Background: involves: C57BL/6J * SJL

homeostasis/metabolism

decreased intestinal cholesterol absorption ( J:78963 , J:100491 )

• 50% (J:78963)

• 40% (J:100491)

steatorrhea ( J:78963 )

• in female but not male mice

decreased circulating phytosterol level ( J:78963 , J:100491 )

• plasma sitosterol levels are decreased 64% and 79% in males and females, respectively, compared to in wild-type mice (J:78963)

• plasma levels of plant sterol and campesterol are reduced compared to in wild-type mice (J:78963)

• however, the plasma levels of lathosterol are normal (J:78963)

• plasma sitosterol and campesterol levels are decreased compared to in wild-type mice (J:100491)

abnormal cholesterol homeostasis ( J:78963 )

• cholesterol synthesis is increased 3-fold in the female duodenum, decreased in male jejunum and ileum, and decreased in the female ileum compared to in wild-type mice

• however, fatty acid synthesis is normal

decreased circulating cholesterol level ( J:78963 )

• in fasting female mice

decreased circulating HDL cholesterol level ( J:78963 )

• in fasting female mice

increased cholesterol level ( J:78963 )

• bile cholesterol levels are increased 5-fold in male mice and 7-fold in female mice compared to in wild-type mice

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:78963 )

• when fed a high fat diet

abnormal bile composition ( J:78963 , J:100491 )

• bile cholesterol levels are increased 5-fold in male mice and 7-fold in female mice compared to in wild-type mice (J:78963)

• bile cholesterol levels are increased compared to in wild-type mice (J:100491)

digestive/alimentary system

abnormal intestinal absorption ( J:100491 )

• campesterol and sitosterol absorption are decreased compared to in wild-type mice

decreased intestinal cholesterol absorption ( J:78963 , J:100491 )

• 50% (J:78963)

• 40% (J:100491)

abnormal feces composition ( J:78963 , J:100491 )

• feces sterol levels are 3-fold higher in males and 6-fold higher in females compared to in wild-type mice (J:78963)

• fecal sterol excretion is increased 2- to 3-fold compared to in wild-type mice (J:100491)

steatorrhea ( J:78963 )

• in female but not male mice