Phenotypes associated with this allele

• Allele Symbol: Nmu^tm1Mko
• Allele Name: targeted mutation 1, Masayasu Kojima
• Allele ID: MGI:3056512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nmu^tm1Mko/Nmu^tm1Mko	involves: 129 * C57BL/6	MGI:3056789

Genotype
MGI:3056789

hm1

• Allelic Composition: Nmu^tm1Mko/Nmu^tm1Mko
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased fat cell size ( J:93213 )

• larger adipocytes in epididymal fat

behavior/neurological

polyphagia ( J:93213 )

• 32.8% increase in daily food consumption and food consumption during both dark and light phases

decreased locomotor activity ( J:93213 )

• 56.2% decrease in motor activity

abnormal circadian behavior ( J:93213 )

• circadian rhythm lost for diurnal feeding

growth/size/body

obese ( J:93213 )

• 35% increase in male body weight at 32 weeks and females also became obese when maintained ad libitum on ordinary mouse chow

• increase in fat mass from about 20% in wild-type to about 52% in mutants

homeostasis/metabolism

impaired adaptive thermogenesis ( J:93213 )

• fail to induce thermogenesis after cold exposure

increased circulating leptin level ( J:93213 )

• twofold increase at 24 weeks

decreased oxygen consumption ( J:93213 )

• reduced to 81% of that in wild-type

abnormal glucose homeostasis ( J:93213 )

hyperglycemia ( J:93213 )

• higher levels of plasma glucose at 56 weeks but not at 24 weeks

increased circulating insulin level ( J:93213 )

abnormal lipid homeostasis ( J:93213 )

decreased circulating corticosterone level ( J:93213 )

increased circulating cholesterol level ( J:93213 )

increased circulating free fatty acids level ( J:93213 )

increased triglyceride level ( J:93213 )

liver/biliary system

hepatic steatosis ( J:93213 )