All Phenotypes Etv6<tm2Sho> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Etv6^tm2Sho
targeted mutation 2, Stuart H Orkin
MGI:3056142

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv6^tm2Sho/Etv6^tm2Sho	involves: 129S1/Sv	MGI:3056262
cn2	Etv6^tm2Sho/Etv6^tm2Sho Tg(Gata1-cre)1Sho/?	involves: 129S1/Sv	MGI:3056263
cn3	Etv6^tm2Sho/Etv6^tm2Sho Tg(Mx1-cre)1Cgn/?	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3056264

Allelic Composition	Etv6^tm2Sho/Etv6^tm2Sho
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^tm2Sho mutation (0 available); any Etv6 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:93052 )

Allelic Composition	Etv6^tm2Sho/Etv6^tm2Sho Tg(Gata1-cre)1Sho/?
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^tm2Sho mutation (0 available); any Etv6 mutation (144 available)
Tg(Gata1-cre)1Sho mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte differentiation ( J:93052 )

• megakaryocyte colony forming cells increased 5 fold

thrombocytopenia ( J:93052 )

• platelet count is reduced 50%

cellular

abnormal megakaryocyte differentiation ( J:93052 )

• megakaryocyte colony forming cells increased 5 fold

Allelic Composition	Etv6^tm2Sho/Etv6^tm2Sho Tg(Mx1-cre)1Cgn/?
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^tm2Sho mutation (0 available); any Etv6 mutation (144 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased neutrophil cell number ( J:93052 )

• moderately reduced neutrophile counts

thrombocytopenia ( J:93052 )

• dramatically reduced platelet counts

• platelet recovery after about 4 weeks

immune system

decreased neutrophil cell number ( J:93052 )

• moderately reduced neutrophile counts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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