All Phenotypes Etv6<tm2Sho> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Etv6^tm2Sho
targeted mutation 2, Stuart H Orkin
MGI:3056142

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv6^tm2Sho/Etv6^tm2Sho	involves: 129S1/Sv	MGI:3056262
cn2	Etv6^tm2Sho/Etv6^tm2Sho Tg(Gata1-cre)1Sho/?	involves: 129S1/Sv	MGI:3056263
cn3	Etv6^tm2Sho/Etv6^tm2Sho Tg(Mx1-cre)1Cgn/?	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3056264

Allelic Composition	Etv6^tm2Sho/Etv6^tm2Sho
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^tm2Sho mutation (0 available); any Etv6 mutation (142 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:93052 )

Allelic Composition	Etv6^tm2Sho/Etv6^tm2Sho Tg(Gata1-cre)1Sho/?
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^tm2Sho mutation (0 available); any Etv6 mutation (142 available)
Tg(Gata1-cre)1Sho mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte differentiation ( J:93052 )

• megakaryocyte colony forming cells increased 5 fold

thrombocytopenia ( J:93052 )

• platelet count is reduced 50%

cellular

abnormal megakaryocyte differentiation ( J:93052 )

• megakaryocyte colony forming cells increased 5 fold

Allelic Composition	Etv6^tm2Sho/Etv6^tm2Sho Tg(Mx1-cre)1Cgn/?
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^tm2Sho mutation (0 available); any Etv6 mutation (142 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased neutrophil cell number ( J:93052 )

• moderately reduced neutrophile counts

thrombocytopenia ( J:93052 )

• dramatically reduced platelet counts

• platelet recovery after about 4 weeks

immune system

decreased neutrophil cell number ( J:93052 )

• moderately reduced neutrophile counts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23