Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rs1tm1Sie mutation
(0 available);
any
Rs1 mutation
(6 available)
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vision/eye
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• diminished dark-adapted ERG b-wave
• Irregular ERG with higher intensity stimulation
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Allelic Composition |
Rs1tm1Sie/Y
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Genetic Background |
involves: 129S/SvEv * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rs1tm1Sie mutation
(0 available);
any
Rs1 mutation
(6 available)
|
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vision/eye
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• innermost "RGC" layer with increased number of cells and some mislocated
• no progressive degeneration through six months of age
• photoreceptor number in the outer nuclear layer slightly reduced
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• large and frequent cavities from age 1 month, peaking at age 4 months and reducing from age 6 months
• no cavities at age 16 months
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• large and frequent cavities from age 1 month, peaking at age 4 months and reducing from age 6 months
• no cavities at age 16 months
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• progressive reduction in cell number
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• large and frequent cavities from age 1 month, peaking at age 4 months and reducing from age 6 months
• no cavities at age 16 months
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• some nuclei displaced from ONL to inner and outer segment
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• disrupted alignment from age 1 month, peaking at age 4 months and progressively normalizing thereafter
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• at age 1 months and progressively declining from age 6 months
• normal height at age 4 months
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• disrupted alignment from age 1 month, peaking at age 4 months and progressively normalizing thereafter
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• irregular laminations in the inner nuclear layer and outer plexiform layer
• structural gaps in the inner nuclear layer
• clumps of photoreceptor nuclei mislocated to the inner and outer segments
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• abnormal b/a wave ratio: lower up to age 6 months, then higher from age 8 months
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• progressive reduction with age at all stimulus intensity levels with scotopic ERG
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• progressive reduction with age at all stimulus intensity levels with scotopic ERG
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• diminished dark-adapted ERG b-wave
• Irregular ERG with higher intensity stimulation
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nervous system
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• disrupted alignment from age 1 month, peaking at age 4 months and progressively normalizing thereafter
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• at age 1 months and progressively declining from age 6 months
• normal height at age 4 months
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• disrupted alignment from age 1 month, peaking at age 4 months and progressively normalizing thereafter
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