Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Moga mutation
(0 available);
any
Mapk1 mutation
(40 available)
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mortality/aging
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• phenotype is stated to be identical to that of Mapk1tm1Moga homozygotes; however no data are presented in J:89903
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embryo
growth/size/body
cardiovascular system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Moga mutation
(0 available);
any
Mapk1 mutation
(40 available)
Mapk3tm1Gpg mutation
(1 available);
any
Mapk3 mutation
(26 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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immune system
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• two weeks after Cre induction by pI-pC injection, the ratio of BP-1+HAShigh cells to BP-1+HASlow cells is much lower than in controls indicating a defect in the transition from pro-B cells to pre-B cells
• there is a 6-fold reduction in the percentage of pro B cells in the bone marrow that are in the S phase
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• bone marrow from mutant mice that have had induction of Cre by pI-pC injection are unable to reconstitute the B cell compartment in irradiated alymphoid mice
• reconstitution still fails when pro B cells are encouraged to differentiate by injection of Igbeta antibodies into the host mice
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• two weeks after Cre induction by pI-pC injection, pre-B cell (B220lowIgM-Cd43-) numbers in the bone marrow are 7% of controls
• immature B cells (B220lowIgM+Cd43-) in the bone marrow are also reduced by a similar amount
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hematopoietic system
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• two weeks after Cre induction by pI-pC injection, the ratio of BP-1+HAShigh cells to BP-1+HASlow cells is much lower than in controls indicating a defect in the transition from pro-B cells to pre-B cells
• there is a 6-fold reduction in the percentage of pro B cells in the bone marrow that are in the S phase
|
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• bone marrow from mutant mice that have had induction of Cre by pI-pC injection are unable to reconstitute the B cell compartment in irradiated alymphoid mice
• reconstitution still fails when pro B cells are encouraged to differentiate by injection of Igbeta antibodies into the host mice
|
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• two weeks after Cre induction by pI-pC injection, pre-B cell (B220lowIgM-Cd43-) numbers in the bone marrow are 7% of controls
• immature B cells (B220lowIgM+Cd43-) in the bone marrow are also reduced by a similar amount
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