All Phenotypes Btrc<tm1Paga> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Btrc^tm1Paga/Btrc^tm1Paga	involves: 129S2/SvPas	MGI:3056062
cn2	Btrc^tm1Paga/Btrc^tm1Paga Fbxw11^tm1Ybn/Fbxw11^tm1Ybn Tg(Vil1-cre/ERT2)23Syr/?	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5568951
cn3	Btrc^tm1Paga/Btrc⁺ Fbxw11^tm1Ybn/Fbxw11^tm1Ybn Tg(Vil1-cre/ERT2)23Syr/?	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5568952

Allelic Composition	Btrc^tm1Paga/Btrc^tm1Paga
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btrc^tm1Paga mutation (2 available); any Btrc mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:93010 )

• homozygous mice appeared generally as healthy as wildtype littermates over 2 years' observation

• almost all mutants revealed no gross tissue abnormalities upon necropsy

• exceptions were a single invasive intestinal carcinoma in a 10 month-old mouse and death due to thymic lymphoma of 2 mice aged 6.5 and 9 months

cellular

oligozoospermia ( J:93010 )

• histological examination of epidydimes of homozygous males revealed severely diminished numbers of mature spermatozoa

abnormal centrosome morphology ( J:93010 )

• approximately 20% of asynchronously dividing MEFs were found to have supernumerary centrosomes

abnormal male meiosis ( J:93010 )

• histological examination of epidydimes of homozygous males revealed evidence of prolonged, abnormal meiosis

• numbers of metaphase I spermatocytes were elevated

• in some mice, spindle abnormalities and misaligned chromosomes were observed

• the degree of fertility impairment correlated with the severity of histologic abnormality

abnormal meiotic spindle morphology ( J:93010 )

• in some spermatocytes, spindle abnormalities and misaligned chromosomes were observed

abnormal mitosis ( J:93010 )

• cultured homozygous mouse embryonic fibroblasts (MEFs) were retarded in their progression through mitosis, despite normal passage from G1 to S phase

• MEFs exhibited misalignment of chromosomes at the metaphase plate

• approximately 20% of asynchronously dividing MEFs were found to have supernumerary centrosomes, and approximately 12% of dividing MEFs exhibited multipolar spindles

abnormal mitotic spindle morphology ( J:93010 )

• approximately 12% of dividing MEFs exhibited multipolar spindles

reproductive system

oligozoospermia ( J:93010 )

• histological examination of epidydimes of homozygous males revealed severely diminished numbers of mature spermatozoa

abnormal male meiosis ( J:93010 )

• histological examination of epidydimes of homozygous males revealed evidence of prolonged, abnormal meiosis

• numbers of metaphase I spermatocytes were elevated

• in some mice, spindle abnormalities and misaligned chromosomes were observed

• the degree of fertility impairment correlated with the severity of histologic abnormality

abnormal meiotic spindle morphology ( J:93010 )

• in some spermatocytes, spindle abnormalities and misaligned chromosomes were observed

reduced male fertility ( J:93010 )

• approximately 50% of homozygous male mice produced no progeny when paired with wild-type females

• fertility defect was not behavioral in origin, as mating behavior was normal and vaginal plugs were observed

• productive homozygous males sired fewer and smaller litters, on average, than did wild-type males

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

rectal hemorrhage ( J:206654 )

• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

abnormal enterocyte morphology ( J:206654 )

• wide gaps in epithelial tight junctions found in enterocytes following tamoxifen administration

abnormal intestinal mucosa morphology ( J:206654 )

• loss of most epithelial cells in large intestine following tamoxifen administration

• remaining mucosa is infiltrated with inflammatory and immune cells

• intestinal barrier disruption observed as early as 24 hours after tamoxifen treatment

abnormal large intestine crypts of Lieberkuhn morphology ( J:206654 )

• unrecognizable crypt structures in large intestine by day 5 following tamoxifen administration

abnormal colon morphology ( J:206654 )

• mice develop severe colitis following tamoxifen administration

• loss of most epithelial cells in large intestine following tamoxifen administration

• remaining mucosa is infiltrated with inflammatory and immune cells

diarrhea ( J:206654 )

• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

intestinal inflammation ( J:206654 )

• inflammation in small and large intestines following tamoxifen administration

cellular

abnormal centrosome morphology ( J:206654 )

• more than 2 centrosomes observed in enterocytes following tamoxifen administration

abnormal mitosis ( J:206654 )

• mitosis is abnormally prolonged in enterocytes following tamoxifen administration

abnormal mitotic spindle morphology ( J:206654 )

• mitotic enterocytes have abnormal spindles following tamoxifen administration

chromosomal instability ( J:206654 )

• observed in enterocytes following tamoxifen administration

cardiovascular system

rectal hemorrhage ( J:206654 )

• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:206654 )

• unrecognizable crypt structures in large intestine by day 5 following tamoxifen administration

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:206654 )

• increase in IL1b levels beginning day 1 and spiking on day 3 following tamoxifen administration

immune system

intestinal inflammation ( J:206654 )

• inflammation in small and large intestines following tamoxifen administration

increased circulating interleukin-1 beta level ( J:206654 )

• increase in IL1b levels beginning day 1 and spiking on day 3 following tamoxifen administration

mortality/aging

premature death ( J:206654 )

• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

Allelic Composition	Btrc^tm1Paga/Btrc⁺ Fbxw11^tm1Ybn/Fbxw11^tm1Ybn Tg(Vil1-cre/ERT2)23Syr/?
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btrc^tm1Paga mutation (2 available); any Btrc mutation (47 available)
Fbxw11^tm1Ybn mutation (0 available); any Fbxw11 mutation (71 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:206654 )

• severe inflammation and a disrupted epithelial layer occurs 4 days after tamoxifen administration

abnormal enterocyte morphology ( J:206654 )

• wide gaps in enterocyte epithelial tight junctions following tamoxifen administration

abnormal intestinal mucosa morphology ( J:206654 )

• mucositis observed in colon following tamoxifen administration

• spontaneous recovery occurs 3 weeks after tamoxifen administration

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